Fig. 6.

TRIM21 regulates TP53-mediated apoptosis and inflammasome activation. TRIM21 activates the formation of mature CASP8 and CASP1 and activates the inflammasome. TRIM21 also activates BAX-BAK1-mediated mitochondrial membrane pore formation and SIVA1- and TP53-mediated ASC transcription. In C. elegans, TRIM21 induces ubiquitination of CED1 to form a cell corpse. TRIM21, tripartite motif containing 21, TP53; Tumor protein p53, CASP8, Caspase 8, CASP1; Caspase 1, CASP3; Caspase 3, CASP7; Caspase 7, BAX; BCL2 associated X, apoptosis regulator, BAK1; BCL2 antagonist/killer 1, SIVA1; SIVA1 apoptosis-inducing factor, ASC/CARD; Apoptosis-associated speck-like protein containing a caspase recruitment domain, C. elegans; Caenorhabditis elegans, CED1; Cell death abnormality protein 1, B2M; Beta-2-microglobulin, TRIM21; Tripartite motif containing 21, Ub; Ubiquitin, UBC21; Ubiquitin-conjugating enzyme 21, RBC; Red blood cell