Table 1.
Structural features of TRIM proteins involved in autophagy and apoptosis
| Autophagy | Apoptosis | Autophagy + Apoptosis | Classification | Domains [N–C] |
|---|---|---|---|---|
| TRIM1 | C-I-2 | R-B1-B2-CC-COS-FN3-SPRY | ||
| TRIM63 | C-II | R-B2-CC-COS-ACID | ||
| TRIM6, TRIM11, TRIM50 | TRIM27 | TRIM17, TRIM20, TRIM21, TRIM35, TRIM39, TRIM72 | C-IV-1 | R-B2-CC-PRY-SPRY |
| TRIM5 | TRIM34 | TRIM22 | C-IV-2 | R-B2-CC-SPRY |
| TRIM69 | C-IV-4 | R-CC-PRY-SPRY | ||
| TRIM14 | TRIM16 | C-IV-4? | B2-CC-PRY-SPRY | |
| TRIM49 | TRIM48 | C-IV-5 | R-B2-SPRY | |
| TRIM8, TRIM19 | C-V-1 | R-B1-B2-CC | ||
| TRIM31 | C-V-2 | R-B2-CC | ||
| TRIM28 | C-VI | R-B1-B2-CC-PHD-BROMO | ||
| TRIM32 | C-VII-3 | R-B2-CC-NHL | ||
| TRIM37 | C-VIII | R-B2-CC-MATH | ||
| TRIM23 | C-IX | R-B1-B2CC-ARF | ||
| TRIM59 | TRIM13 | C-XI | R-B2-CC-TM |
Most TRIM proteins contain a RING-finger domain, one or two B-box (B1 or B2) domains, and a coiled-coil domain
TRIM proteins were classified as C-I to C-XI. TRIM proteins without a RING finger domain (no RING) were unclassified
R, RING-finger domain; B1, B-box domain 1; B2, B-box domain 2; CC, coiled-coil domain; COS, cos box; FN3, fibronectin type III repeat; PRY, PRY domain; SPRY, SPRY domain; ACID, acid-rich region; NHL, NHL domain; PHD, PHD domain; BROMO, bromodomain; MATH, Meprin and TRAF-homology domain; ARF, ADP-ribosylation factor family domain; TM, transmembrane domain. TRIM; Tripartite motif containing, RING, Really interesting new gene, C-I; Class I, N–C; N-terminal-C-terminal domain