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. Author manuscript; available in PMC: 2024 Jan 16.
Published in final edited form as: J Med Chem. 2021 Jun 9;64(12):8042–8052. doi: 10.1021/acs.jmedchem.1c00482

Figure 4.

Figure 4.

Recent advances in computational approaches to PROTAC development. MOE: General approach and highlights of the protocol used by Drummond et. al.36 on the Molecular Operating Environment (MOE) platform. PRosettaC: General approach and highlights of the protocol used by Zaidman et al.42 on the Rosetta platform. Rosetta: General approach and highlights of the protocol used by Bai et al.46 on the Rosetta platform.