Anticancer activity, determined by MTT assays after 72 h treatment. IC50 values (μM) are given as mean ± SD.
| Drugs | Capan1 | Capan1/GemR | -fold resistance |
|---|---|---|---|
| IC50 (μM) ± SD | |||
| Gemcitabine | 0.029 ± 0.013 | 83.7 ± 5.1 | 2790.0 |
| Cisplatin | 4.3 ± 0.7 | 4.2 ± 0.7 | 1.0 |
| CisPt(OAc)2 | 41.7 ± 13.8 | 88.8 ± 2.5 | 2.1 |
| CisPt-GemCarb-OAc | 0.12 ± 0.03 | 20.4 ± 2.3 | 170.0 |
| CisPt-GemSucc-OAc | 0.046 ± 0.011 | 26.1 ± 8.0 | 522.0 |
| Carboplatin | 50.4 ± 9.7 | 35.7 ± 2.7 | 0.7 |
| CarboPt(OAc)2 | 94.7 ± 0.5 | >100 | >1.0 |
| CarboPt-GemSucc-OAc | 0.086 ± 0.002 | 73.3 ± 17.6 | 916.3 |