Table 3.
Drug class | Generic | Brand name | ||
---|---|---|---|---|
|
|
|||
Cost rage, $ | Cost variation, $ | Cost range, $ | Cost variation, $ | |
Angiotensin-converting-enzyme inhibitors | ||||
| ||||
Enalapril | 25.73–74.01 | 48.28 | 134.64–411.03 | 276.39 |
| ||||
Lisinopril | 26.00–76.01 | 50.01 | 96.93–747.00 | 650.07 |
| ||||
Perindopril | 27.52–52.01 | 24.49 | 89.01–363.39 | 274.38 |
| ||||
Ramipril | 7.94–65.17 | 57.23 | 83.55–264.03 | 180.48 |
| ||||
Trandolapril | 22.44–56.45 | 34.01 | 87.90–150.00 | 62.10 |
| ||||
Angiotensin receptor blockers | ||||
| ||||
Candesartan | 22.17–48.45 | 26.28 | 138.93–399.72 | 260.79 |
| ||||
Valsartan | 15.54–61.01 | 45.47 | 125.79–452.70 | 326.91 |
| ||||
Antiplatelet agents | ||||
| ||||
ASA | 10.35–21.90 | 11.55 | 16.35–66.57 | 50.22 |
| ||||
Clopidogrel | 25.57–59.41 | 33.84 | 271.74–384.03 | 112.29 |
| ||||
Direct factor Xa inhibitor | ||||
| ||||
Rivaroxaban, 2.5 mg twice daily | NA | — | 129.15–174.66 | 45.51 |
| ||||
Statins | ||||
| ||||
Atorvastatin | 23.19–45.21 | 22.02 | 246.03–348.30 | 102.27 |
| ||||
Rosuvastatin | 19.71–50.16 | 30.45 | 198.03–291.03 | 93.00 |
ASA = acetylsalicylic acid; NA = not applicable.
Cost represents that of the maximum evidence-based dosage of each drug, except that the enalapril dosage was 10 mg twice daily (the American College of Cardiology guideline’s maximum dosage is 20 mg twice daily, but only for patients categorized as New York Heart Association Functional Class IV12), and the rivaroxaban dosage was 2.5 mg twice daily, in keeping with the COMPASS regimen therapy.14