Table 1.
Data on analogs (5a-j)’s neurotoxicity and anticonvulsant screening
Compound Number | Mice receiving an intraperitoneal/subcutaneous injectiona | ||||||
---|---|---|---|---|---|---|---|
| |||||||
MES assessment | scPTZ assessment | Neurotoxicity assessment | Ethanol potentiation test | ||||
|
|
|
|||||
Half hour | 4 h | Half hour | 4 h | Half hour | 4 h | ||
5a | 300 | 300 | 300 | 300 | X | X | X |
5b | 100 | 100 | 100 | 100 | - | - | - |
5c | 300 | 300 | 300 | 300 | X | X | X |
5d | 100 | 100 | 100 | 100 | - | - | - |
5e | 100 | 300 | 100 | 300 | - | - | - |
5f | 30 | 100 | 100 | 100 | - | - | - |
5 g | 300 | 300 | 300 | 300 | + | + | X |
5h | 100 | 100 | 100 | 100 | - | - | - |
5i | - | - | X | X | - | + | X |
5j | 100 | 300 | 100 | 300 | - | - | - |
Phenytoin | 30 | 30 | - | - | 100 | 100 | - |
Carbamazepine | 30 | 100 | 100 | 300 | 100 | 300 | - |
a30 mg/kg, 100 mg/kg, and 300 mg/kg of the drug were administered. After 0.5 and 4 h, the protective effect and neurotoxicity were studied. The results showed how much of a minimum dose of lead was needed to protect 50% or more of the animals or cause neurotoxicity in at least 50% of them. The dash (—) meant that neither neurotoxicity nor anticonvulsant action was present in these compounds. X— means that it was not analyzed. bEthanol potentiation test: (+) means that at least half of the animals had positive results; [–]means that at least half of the animals had negative results. X— stands for “not tested”