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. 2023 Dec 11;15(4):205–211. doi: 10.4103/jpbs.jpbs_478_23

Table 1.

Data on analogs (5a-j)’s neurotoxicity and anticonvulsant screening

Compound Number Mice receiving an intraperitoneal/subcutaneous injectiona

MES assessment scPTZ assessment Neurotoxicity assessment Ethanol potentiation test



Half hour 4 h Half hour 4 h Half hour 4 h
5a 300 300 300 300 X X X
5b 100 100 100 100 - - -
5c 300 300 300 300 X X X
5d 100 100 100 100 - - -
5e 100 300 100 300 - - -
5f 30 100 100 100 - - -
5 g 300 300 300 300 + + X
5h 100 100 100 100 - - -
5i - - X X - + X
5j 100 300 100 300 - - -
Phenytoin 30 30 - - 100 100 -
Carbamazepine 30 100 100 300 100 300 -

a30 mg/kg, 100 mg/kg, and 300 mg/kg of the drug were administered. After 0.5 and 4 h, the protective effect and neurotoxicity were studied. The results showed how much of a minimum dose of lead was needed to protect 50% or more of the animals or cause neurotoxicity in at least 50% of them. The dash (—) meant that neither neurotoxicity nor anticonvulsant action was present in these compounds. X— means that it was not analyzed. bEthanol potentiation test: (+) means that at least half of the animals had positive results; [–]means that at least half of the animals had negative results. X— stands for “not tested”