TABLE 3.
Relationships between antibody levels to the Als3 and Mp65 antigens and 30-day survival in different subgroups of patientsa
| Group | Variables | |||
|---|---|---|---|---|
| Anti-Als3 titer | Anti-Mp65 titer | Other variables in the model (OR, P) | ||
| All patients (n = 92) | OR = 3.10 (1.3–7.4 95% CI) P= 0.011* |
OR = 2.46 (0.7–8.2 95% CI) P = 0.10 |
Diabetes (0.17, 0.014*) Glucanemia (0.33, 0.005*) Septic shock (0.11, 0.0004*) Fluconazole (0.21, 0.037* |
AUC = 0.858 (0.77–0.92 95% Cl) P (F test) < 0.0001* |
| Septic shock (n = 32) | OR = 4.34 (1.3–14.0 95% CI) P= 0.019* |
ni | No other variable | AUC = 0.746 (0.58–0.87 95% Cl) P (F test) = 0.009* |
| Age > 72 (n=46) | OR = 10.0 (1.6–42 95% CI) P= 0.013* |
ni |
C. albicans (0.22, 0.085) APACHE (0.88, 0.029*) Glucanemia (0.33, 0.046*) Caspofungin (3,3, 0.036*) |
AUC = 0.839 (0.70–0.93 95% Cl) P (F test) = 0.001* |
| C. albicans (n=47) | OR = 5.11 (1.3–21 95% CI) P= 0.024* |
ni | Diabetes (0.12, 0.034*) Glucanemia (0.34, 0.045*) Septic shock (0.08, 0.012*) Fluconazole (0.094,0.058) |
AUC = 0.815, (0.73–0.94 95% Cl) P (F test) = 0.0007* |
| No septic shock (n = 53) | ni | OR = 4.41 (1.2–18 95% CI) P= 0.037* |
Glucanemia (0.13, 0.036*) Chronic renal failure (0.26, 0087) |
AUC = 0.841 (0.71–0.93 95% Cl) P (F test) = 0.0016* |
| Age ≤ 72 (n = 46) | ni | OR = 13.4 (1.9–57 95% CI) P= 0.001* |
Septic shock (0.08, 0.013*) Antibiotics (3.3, 0.059) |
AUC = 0.885 (0.75–0.93 95% Cl) P (F test) = 0.0002* |
| Non-albicans species (n = 45) | ni | OR = 6.42 (1.2–34 95% Cl) P= 0.031* |
Diabetes (0.12, 0.085) Glucanemia (0.09, 0.025*) Fluconazole (0.096, 0.070) |
AUC = 0.849 (0.71–0.91 95% Cl) P (F test) = 0.003* |
The table reports complete logistic regression models for prediction of survival in the indicated patient groups. Independent variables initially considered were those reported in Table 1 and titer values of all four investigated anti-Candida antibodies. Model variables were selected using the “backward” algorithm, with cut-off for model inclusion at P < 0.1. OR, odds ratio; 95% Cl, 95% confidence limits; AUC, area under curve; ni, not included in the final model (P > 0.1). Anti-Hyr1 and anti-Eno1 IgG showed no association to survival (P > 0.1) in all patient groups and are not mentioned in the table. * The asterisks indicate P < 0.05.