Table 1.
Antiproliferative activity of all compounds.
| Compounds | (IC50 ± SD, μM)a |
||
|---|---|---|---|
| HeLa | SGC-7901 | MCF-7 | |
| 10a | 2.15 ± 0.19 | 8.82 ± 0.83 | 4.7 ± 0.55 |
| 10b | 21.9 ± 1.69 | > 30 | > 30 |
| 10c | 4.7 ± 0.53 | 9.2 ± 0.98 | 10.2 ± 1.6 |
| 10d | 1.2 ± 0.22 | 1.4 ± 0.18 | 2.22 ± 0.21 |
| 10e | 3.7 ± 0.44 | 5.7 ± 0.62 | 9.4 ± 1.1 |
| 10f | 9.4 ± 1.0 | 13.3 ± 2.0 | 15.7 ± 3.5 |
| 10g | 8.3 ± 1.8 | 20.2 ± 2.8 | 17.2 ± 3.7 |
| 10h | 1.9 ± 0.46 | 4.5 ± 0.48 | 3.2 ± 0.11 |
| 10i | 0.48 ± 0.10 | 0.63 ± 0.16 | 0.95 ± 0.21 |
| 10j | 0.90 ± 0.20 | 1.61 ± 0.36 | 1.36 ± 0.37 |
| 10k | 7.0 ± 0.54 | 13.1 ± 1.5 | 9.4 ± 1.8 |
| 10l | 5.3 ± 0.34 | 9.6 ± 1.3 | 7.0 ± 1.1 |
| 10m | 12.0 ± 2.6 | > 30 | > 30 |
| 10n | > 30 | > 30 | > 30 |
| 10o | > 30 | > 30 | > 30 |
| 10p | 23.0 ± 4.4 | > 30 | > 30 |
| 10q | 0.49 ± 0.12 | 3.9 ± 0.52 | 2.6 ± 0.40 |
| 10r | 19.9 ± 4.6 | > 30 | > 30 |
| 10s | 10.2 ± 2.3 | 15.9 ± 5.5 | 16.5 ± 3.7 |
| 10t | 0.12 ± 0.02 | 0.15 ± 0.04 | 0.21 ± 0.05 |
| CA-4 b | 0.047 ± 0.010 | 0.068 ± 0.014 | 0.089 ± 0.026 |
a
IC50: the half maximal inhibitory concentration.
b
Used as positive controls.