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. 2024 Jan 14;39(1):2302920. doi: 10.1080/14756366.2024.2302920

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© 2024 Gdansk University of Technology. Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Inhibition of Topo IIα (a) and IIβ (b) mediated pBR322 relaxation. The experiment was carried out either with Topo IIα/IIβ in the presence of solvent (DMSO IIα/IIβ (+)) or with various concentrations of carbazole derivatives. ETP (100 µM), and ICRF-187 (100 µM) were used as references. (c) Unwinding assay. Determination of the ability of carbazole derivatives to intercalate into DNA in the presence of topoisomerase I (Top I). ETP and DOXO were used as negative and positive controls, respectively. The displayed gels have been cropped for clarity; full-length gels can be found in Supplementary Figures S1–S3.