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Inhibition of Topo IIα/IIβ mediated kDNA decatenation by carbazole derivatives (a, b). DNA cleavage assay in the presence of 36a, 36b, and 27a, respectively (c, d). ETP (100 µM) and ICRF-187 (100 µM) were used as references. The displayed gels have been cropped for clarity; full-length gels can be found in Supplementary Figures S4–S7.
