Table 5.
Univariate and Multivariate Logistic Regression Analysis of Risk Factors for Impaired Long-term QOL after IPAA
| Variable | Impaired long-term QOL group (n=85) | Significantly improved long-term QOL group (n=123) | Univariate analysis p-value |
Multivariate logistic regression | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | |||||
| Age at diagnosis | 0.012* | 2.214 (1.170–3.855) | 0.013 | |||
| <40 yr | 32 (37.6) | 68 (55.3) | ||||
| ≥40 yr | 53 (62.4) | 55 (44.7) | ||||
| Body mass index | 0.278* | |||||
| ≥18.5 kg/m2 | 62 (72.9) | 81 (65.9) | ||||
| <18.5 kg/m2 | 23 (27.1) | 42 (34.1) | ||||
| Disease duration | 0.400* | |||||
| <5 yr | 54 (63.5) | 85 (69.1) | ||||
| ≥5 yr | 31 (36.5) | 38 (30.9) | ||||
| First occurrence | 0.599† | |||||
| Yes | 14 (16.5) | 17 (13.8) | ||||
| No | 71 (83.5) | 106 (86.2) | ||||
| Extent of ulcerative colitis | 0.634† | |||||
| E1 (proctitis) | 14 (16.5) | 23 (18.7) | ||||
| E2 (left-sided colitis) | 7 (8.2) | 11 (8.9) | ||||
| E3 (pancolitis) | 64 (75.3) | 89 (72.4) | ||||
| Extraintestinal manifestation | 0.599* | |||||
| No | 74 (87.1) | 110 (89.4) | ||||
| Yes | 11 (12.9) | 13 (10.6) | ||||
| Mesalamine | 0.411* | |||||
| No | 28 (32.9) | 34 (27.6) | ||||
| Yes | 57 (67.1) | 89 (72.4) | ||||
| Immunomodulators | 0.224* | |||||
| No | 64 (75.3) | 83 (67.5) | ||||
| Yes | 21 (24.7) | 40 (32.5) | ||||
| Steroids | 0.618* | |||||
| No | 34 (40.0) | 45 (36.6) | ||||
| Yes | 51 (60.0) | 78 (63.4) | ||||
| Biologics | 0.271* | |||||
| No | 70 (82.4) | 108 (87.8) | ||||
| Yes | 15 (17.6) | 15 (12.2) | ||||
| Stage of surgery | 0.757† | |||||
| II-stage IPAA | 55 (64.7) | 77 (62.6) | ||||
| III-stage IPAA | 30 (35.3) | 46 (37.4) | ||||
| Surgical urgency | 0.934† | |||||
| Urgent surgery | 8 (9.4) | 12 (9.8) | ||||
| Elective surgery | 77 (90.6) | 111 (90.2) | ||||
| Surgical approach | 0.002* | 3.268 (1.688–6.326) | <0.001 | |||
| Open surgery | 35 (41.2) | 26 (21.1) | ||||
| Laparoscopic surgery | 50 (58.8) | 97 (78.9) | ||||
| Pouch length | 0.015* | 2.221 (1.218-4.050) | 0.009 | |||
| Short J pouch | 47 (55.3) | 47 (38.2) | ||||
| Long J pouch | 38 (44.7) | 76 (61.8) | ||||
| Hemoglobin | 0.783* | |||||
| ≥110 g/L | 32 (37.6) | 44 (35.8) | ||||
| <110 g/L | 53 (62.4) | 79 (64.2) | ||||
| Albumin | 0.046* | 1.784 (0.972–3.274) | 0.062 | |||
| ≥35 g/L | 33 (38.8) | 65 (52.8) | ||||
| <35 g/L | 52 (61.2) | 58 (47.2) | ||||
| White blood cell | 0.381* | |||||
| <10×109/L | 68 (80.0) | 92 (74.8) | ||||
| ≥10×109/L | 17 (20.0) | 31 (25.2) | ||||
| Intraoperative blood loss | 0.589* | |||||
| <200 mL | 55 (64.7) | 84 (68.3) | ||||
| ≥200 mL | 30 (35.3) | 39 (31.7) | ||||
Data are presented as number (%).
QoL, quality of life; IPAA, ileal pouch-anal anastomosis; OR, odds ratio; CI, confidence interval.
*Chi-square test; †Wilcoxon rank-sum test.