Skip to main content
. 2024 Jan 16;10:33. doi: 10.1038/s41420-024-01808-8

Fig. 6. HOOK3 overexpression suppressed proliferation and metastasis of GC cells in vivo.

Fig. 6

A The image displayed is representative of HOOK3-overexpressing MKN28 tumors grown in nude mice. The volumes of these tumors were evaluated in groups containing four mice each. B Representative images of immunohistochemistry (IHC) staining for Ki-67 and VEGFA and TUNEL staining were captured in tumor tissues from the OE-HOOK3 and OE-NC groups. The scale bar represents 50 μm. C A murine lung metastasis model was established using HOOK3-overexpressing GC cells and control GC cells, with three mice in each group. D Representative images of hematoxylin and eosin (HE) stains were obtained from lung metastasis in the OE-HOOK3 and OE-NC groups. The scale bar represents 50 μm. The mean values along with standard deviations (SD) were used to represent the data, and statistical significance was determined using Student’s t-test. **P < 0.01.