Table 2.
Allele frequencies and genotype distributions in patients with ADHD and in normal controls, segmented by gender
| Gene | SNP | Model | Genotype | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control/Case | OR (95%CI) | P | Control/Case | OR (95%CI) | P | Control/Case | OR (95%CI) | P | ||||
| DRD2 | rs1124491 | Codominant | G/G | 79/69 | 1 | 0.27 | 49/49 | 1 | 0.89 | 30/20 | 1 | 0.098 |
| A/G | 48/60 | 1.43(0.87–2.36) | 36/41 | 1.14 (0.63–2.07) | 12/19 | 2.37 (0.95–5.95) | ||||||
| A/A | 5/8 | 1.83(0.57–5.86) | 4/5 | 1.25 (0.32–4.93) | 1/3 | 4.50(0.44–46.38) | ||||||
| Dominant | G/G | 79/69 | 1 | 0.12 | 49/49 | 1 | 0.64 | 30/20 | 1 | 0.037 | ||
| A/G-A/A | 53/68 | 1.47(0.91–2.38) | 40/46 | 1.15 (0.64–2.05) | 13/22 | 2.54 (1.04–6.18) | ||||||
| Recessive | G/G-A/G | 127/129 | 1 | 0.43 | 85/90 | 1 | 0.81 | 42/39 | 1 | 0.28 | ||
| A/A | 5/8 | 1.58(0.50–4.94) | 4/5 | 1.18 (0.31–4.54) | 1/3 | 3.23(0.32–32.38) | ||||||
| Overdominat | G/G-A/A | 84/77 | 1 | 0.21 | 53/54 | 1 | 0.71 | 31/23 | 1 | 0.096 | ||
| A/G | 48/60 | 1.36(0.84–2.22) | 36/41 | 1.12 (0.62–2.01) | 12/19 | 2.13 (0.87–5.26) | ||||||
| rs6277 | Codominant | G/G | 87/71 | 1 | 0.025* | 70/52 | 1 | 0.0017* | 17/19 | 1 | 0.74 | |
| G/A | 40/64 | 1.96 (1.18–3.25) | 17/41 | 3.25 (1.66–6.34) | 23/23 | 0.89 (0.37–2.14) | ||||||
| A/A | 6/9 | 1.84 (0.62–5.14) | 4/5 | 1.68 (0.43–6.58) | 2/4 | 1.79(0.29–11.04) | ||||||
| Dominant | G/G | 87/71 | 1 | 0.006* | 70/52 | 1 | 0.00005* | 17/19 | 1 | 0.94 | ||
| G/A-A/A | 46/73 | 1.94 (1.20–3.16) | 21/46 | 2.95 (1.57–5.53) | 25/27 | 0.97 (0.41–2.26) | ||||||
| Recessive | G/G-G/A | 127/135 | 1 | 0.52 | 87/93 | 1 | 0.82 | 40/42 | 1 | 0.46 | ||
| A/A | 6/9 | 1.41 (0.49–4.08) | 4/5 | 1.17 (0.30–4.50) | 2/4 | 1.90(0.33–10.98) | ||||||
| Overdominat | G/G-A/A | 93/80 | 1 | 0.013* | 74/57 | 1 | 0.00005* | 19/23 | 1 | 0.66 | ||
| G/A | 40/64 | 1.86 (1.13–3.05) | 17/41 | 3.13 (1.61–6.07) | 23/23 | 0.83 (0.36–1.91) | ||||||
| rs1079727 | Codominant | T/T | 76/70 | 1 | 0.39 | 48/47 | 1 | 0.88 | 28/23 | 1 | 0.24 | |
| C/T | 49/53 | 1.17 (0.71–1.95) | 36/37 | 1.05 (0.57–1.93) | 13/16 | 1.50 (0.60–3.75) | ||||||
| C/C | 9/15 | 1.81 (0.74–4.40) | 7/9 | 1.31 (0.45–3.81) | 2/6 | 3.65(0.67–19.85) | ||||||
| Dominant | T/T | 76/70 | 1 | 0.32 | 48/47 | 1 | 0.76 | 28/23 | 1 | 0.18 | ||
| C/T-C/C | 58/68 | 1.27 (0.79–2.05) | 43/46 | 1.09 (0.61–1.95) | 15/22 | 1.79 (0.76–4.21) | ||||||
| Recessive | T/T-C/T | 125/123 | 1 | 0.22 | 84/84 | 1 | 0.63 | 41/39 | 1 | 0.15 | ||
| C/C | 9/15 | 1.69 (0.71–4.02) | 7/9 | 1.29 (0.46–3.61) | 2/6 | 3.15(0.60–16.58) | ||||||
| Overdominat | T/T-C/C | 85/85 | 1 | 0.75 | 55/56 | 1 | 0.98 | 30/29 | 1 | 0.6 | ||
| C/T | 49/53 | 1.08 (0.66–1.77) | 36/37 | 1.01 (0.56–1.82) | 13/16 | 1.27 (0.52–3.11) | ||||||
| rs6278 | Codominant | C/C | 75/75 | 1 | 0.83 | 47/53 | 1 | 0.76 | 28/22 | 1 | 0.11 | |
| C/A | 53/60 | 1.13 (0.69–1.85) | 40/42 | 0.93 (0.52–1.67) | 13/18 | 1.76 (0.71–4.36) | ||||||
| A/A | 8/10 | 1.25 (0.47–3.34) | 7/5 | 0.63 (0.19–2.13) | 1/5 | 6.36(0.69–58.50) | ||||||
| Dominant | C/C | 75/75 | 1 | 0.57 | 47/53 | 1 | 0.68 | 28/22 | 1 | 0.092 | ||
| C/A-A/A | 61/70 | 1.15 (0.72–1.83) | 47/47 | 0.89 (0.50–1.56) | 14/23 | 2.09 (0.88–4.98) | ||||||
| Recessive | C/C-C/A | 128/135 | 1 | 0.73 | 87/95 | 1 | 0.48 | 41/40 | 1 | 0.093 | ||
| A/A | 8/10 | 1.19 (0.45–3.10) | 7/5 | 0.65 (0.20–2.14) | 1/5 | 5.12(0.57–45.83) | ||||||
| Overdominat | C/C-A/A | 83/85 | 1 | 0.68 | 54/58 | 1 | 0.94 | 29/27 | 1 | 0.38 | ||
| C/A | 53/60 | 1.11 (0.69–1.78) | 40/42 | 0.98 (0.55–1.73) | 13/18 | 1.49 (0.61–3.60) | ||||||
| rs6275 | Codominant | G/G | 45/22 | 1 | 0.0013* | 30/12 | 1 | 0.0036* | 15/10 | 1 | 0.14 | |
| A/G | 72/86 | 2.44 (1.34–4.44) | 52/67 | 3.22 (1.50–6.90) | 20/19 | 1.43 (0.52–3.94) | ||||||
| A/A | 20/35 | 3.58 (1.69–7.57) | 13/20 | 3.85 (1.46–10.12) | 7/15 | 3.21 (0.97–10.69) | ||||||
| Dominant | G/G | 45/22 | 1 | 0.00006* | 30/12 | 1 | 0.00009* | 15/10 | 1 | 0.18 | ||
| A/G-A/A | 92/121 | 2.69 (1.51–4.79) | 65/87 | 3.35 (1.59–7.03) | 27/34 | 1.89 (0.73–4.87) | ||||||
| Recessive | G/G-A/G | 117/108 | 1 | 0.036* | 82/79 | 1 | 0.23 | 35/29 | 1 | 0.062 | ||
| A/A | 20/35 | 1.90 (1.03–3.48) | 13/20 | 1.60 (0.74–3.43) | 7/15 | 2.59 (0.93-–7.20) | ||||||
| Overdominat | G/G-A/A | 65/57 | 1 | 0.20 | 43/32 | 1 | 0.064 | 22/25 | 1 | 0.68 | ||
| A/G | 72/86 | 1.36 (0.85–2.19) | 52/67 | 1.73 (0.97–3.10) | 20/19 | 0.84 (0.36–1.96) | ||||||
| SLC6A3 | rs2652511 | Codominant | A/A | 70/97 | 1 | 0.013* | 51/66 | 1 | 0.078 | 19/30 | 1 | 0.011* |
| A/G | 54/39 | 0.52 (0.31–0.87) | 38/24 | 0.49 (0.26–0.91) | 16/15 | 0.57 (0.23–1.42) | ||||||
| G/G | 16/9 | 0.41 (0.17–0.97) | 8/8 | 0.77 (0.27–2.20) | 8/1 | 0.08 (0.01–0.80) | ||||||
| Dominant | A/A | 70/97 | 1 | 0.0037* | 51/66 | 1 | 0.035 | 19/31 | 1 | 0.037* | ||
| A/G-G/G | 70/48 | 0.49 (0.31–0.80) | 46/32 | 0.54 (0.30–0.96) | 24/16 | 0.41 (0.17–0.96) | ||||||
| Recessive | A/A-A/G | 124/136 | 1 | 0.12 | 89/90 | 1 | 0.98 | 35/46 | 1 | 0.0061* | ||
| G/G | 16/9 | 0.51 (0.22–1.20) | 8/8 | 0.99 (0.36–2.75) | 8/1 | 0.10 (0.01–0.80) | ||||||
| Overdominat | A/A-G/G | 86/106 | 1 | 0.035 | 59/74 | 1 | 0.027 | 27/32 | 1 | 0.6 | ||
| A/G | 54/39 | 0.59 (0.36–0.97) | 38/24 | 0.50 (0.27–0.93) | 16/15 | 0.79 (0.33–1.89) | ||||||
| rs6347 | Codominant | T/T | 96/103 | 1 | 0.9 | 63/70 | 1 | 0.68 | 33/33 | 1 | 0.45 | |
| T/C | 37/35 | 0.88 (0.51–1.51) | 29/25 | 0.78 (0.41–1.46) | 8/10 | 1.25 (0.44–3.56) | ||||||
| C/C | 3/3 | 0.93 (0.18–4.73) | 2/3 | 1.35 (0.22–8.34) | 1/0 | 0.00 (0.00-NA) | ||||||
| Dominant | T/T | 96/103 | 1 | 0.65 | 63/70 | 1 | 0.51 | 33/33 | 1 | 0.84 | ||
| T/C-C/C | 40/38 | 0.89 (0.52–1.50) | 31/28 | 0.81 (0.44–1.50) | 9/10 | 1.11 (0.40–3.09) | ||||||
| Recessive | T/T-T/C | 133/138 | 1 | 0.96 | 92/95 | 1 | 0.68 | 41/43 | 1 | 0.23 | ||
| C/C | 3/3 | 0.96 (0.19–4.86) | 2/3 | 1.45 (0.24–8.89) | 1/0 | 0.00 (0.00-NA) | ||||||
| Overdominat | T/T-C/C | 99/106 | 1 | 0.65 | 65/73 | 1 | 0.41 | 34/33 | 1 | 0.63 | ||
| T/C | 37/35 | 0.88 (0.52–1.51) | 29/25 | 0.77 (0.41–1.44) | 8/10 | 1.29 (0.45–3.66) | ||||||
| rs2975226 | Codominant | A/A | 41/48 | 1 | 0.72 | 29/29 | 1 | 0.98 | 12/19 | 1 | 0.33 | |
| A/T | 75/71 | 0.81 (0.48–1.37) | 50/49 | 0.98 (0.51–1.87) | 25/22 | 0.56 (0.22–1.40) | ||||||
| T/T | 22/21 | 0.82 (0.39–1.69) | 17/18 | 1.06 (0.46–2.45) | 5/3 | 0.38 (0.08–1.88) | ||||||
| Dominant | A/A | 41/48 | 1 | 0.41 | 29/29 | 1 | 1 | 12/19 | 1 | 0.16 | ||
| A/T-T/T | 97/92 | 0.81 (0.49–1.34) | 67/67 | 1.00 (0.54–1.85) | 30/25 | 0.53 (0.21–1.29) | ||||||
| Recessive | A/A-A/T | 116/119 | 1 | 0.83 | 79/78 | 1 | 0.85 | 37/41 | 1 | 0.42 | ||
| T/T | 22/21 | 0.93 (0.49–1.78) | 17/18 | 1.07 (0.52–2.23) | 5/3 | 0.54 (0.12–2.42) | ||||||
| Overdominat | A/A-T/T | 63/69 | 1 | 0.54 | 46/47 | 1 | 0.89 | 17/22 | 1 | 0.37 | ||
| A/T | 75/71 | 0.86 (0.54–1.38) | 50/49 | 0.96 (0.54–1.69) | 25/22 | 0.68 (0.29–1.60) | ||||||
| GRIN2B | rs1012586 | Codominant | C/C | 45/29 | 1 | 0.079 | 28/17 | 1 | 0.16 | 17/12 | 1 | 0.44 |
| G/C | 64/79 | 1.92 (1.08–3.39) | 49/59 | 1.98 (0.97–4.04) | 1520 | 1.89 (0.70–5.12) | ||||||
| G/G | 25/24 | 1.49 (0.72–3.09) | 16/16 | 1.65 (0.66–4.13) | 9/8 | 1.26 (0.38–4.20) | ||||||
| Dominant | C/C | 45/29 | 1 | 0.034 | 28/17 | 1 | 0.064 | 17/12 | 1 | 0.28 | ||
| G/C-G/G | 89/103 | 1.80 (1.04–3.10) | 65/75 | 1.90 (0.96–3.78) | 24/28 | 1.65 (0.66–4.14) | ||||||
| Recessive | C/C-G/C | 109/108 | 1 | 0.92 | 77/76 | 1 | 0.97 | 32/32 | 1 | 0.83 | ||
| G/G | 25/24 | 0.97 (0.52–1.80) | 16/16 | 1.01 (0.47–2.17) | 9/8 | 0.89 (0.30–2.59) | ||||||
| Overdominat | C/C-G/G | 70/53 | 1 | 0.048 | 44/33 | 1 | 0.11 | 26/20 | 1 | 0.09 | ||
| G/C | 64/79 | 1.63 (1.00–2.65) | 49/59 | 1.61 (0.89–2.89) | 15/20 | 1.73 (0.71–4.21) | ||||||
| rs2268119 | Codominant | A/A | 46/52 | 1 | 0.69 | 36/37 | 1 | 0.68 | 10/15 | 1 | 0.068 | |
| A/T | 69/69 | 0.88 (0.53–1.49) | 47/44 | 0.91 (0.49–1.69) | 22/25 | 0.76 (0.28–2.03) | ||||||
| T/T | 22/18 | 0.72 (0.35–1.51) | 10/14 | 1.36 (0.54–3.46) | 12/4 | 0.22 (0.06–0.89) | ||||||
| Dominant | A/A | 46/52 | 1 | 0.51 | 36/37 | 1 | 0.97 | 10/15 | 1 | 0.24 | ||
| A/T-T/T | 91/87 | 0.85 (0.52–1.39) | 57/58 | 0.99 (0.55–1.78) | 34/29 | 0.57 (0.22–1.46) | ||||||
| Recessive | A/A-A/T | 115/121 | 1 | 0.46 | 83/81 | 1 | 0.41 | 32/40 | 1 | 0.024 | ||
| T/T | 22/18 | 0.78 (0.40–1.52) | 10/14 | 1.43 (0.60–3.41) | 12/4 | 0.27 (0.08–0.91) | ||||||
| Overdominat | A/A-T/T | 68/70 | 1 | 0.9 | 46/51 | 1 | 0.56 | 22/19 | 1 | 0.52 | ||
| A/T | 69/69 | 0.97 (0.61–1.56) | 47/44 | 0.84 (0.48–1.50) | 22/25 | 1.32 (0.57–3.05) | ||||||
| rs1805502 | Codominant | A/A | 85/83 | 1 | 0.37 | 59/59 | 1 | 0.32 | 26/24 | 1 | 0.72 | |
| G/A | 36/49 | 1.39 (0.82–2.36) | 23/32 | 1.39 (0.73–2.65) | 13/17 | 1.42 (0.57–3.52) | ||||||
| G/G | 9/7 | 0.80 (0.28–2.24) | 6/3 | 0.50 (0.12–2.09) | 3/4 | 1.44 (0.29–7.13) | ||||||
| Dominant | A/A | 85/83 | 1 | 0.34 | 59/59 | 1 | 0.55 | 26/24 | 1 | 0.42 | ||
| G/A-G/G | 45/56 | 1.27 (0.78–2.09) | 29/35 | 1.21 (0.66–2.22) | 16/21 | 1.42 (0.60–3.34) | ||||||
| Recessive | A/A-G/A | 121/132 | 1 | 0.51 | 82/91 | 1 | 0.26 | 39/41 | 1 | 0.76 | ||
| G/G | 9/7 | 0.71 (0.26–1.97) | 6/3 | 0.45 (0.11–1.86) | 3/4 | 1.27 (0.27–6.03) | ||||||
| Overdominat | A/A-G/G | 94/90 | 1 | 0.18 | 65/62 | 1 | 0.24 | 29/28 | 1 | 0.5 | ||
| G/A | 36/49 | 1.42 (0.85–2.39) | 23/32 | 1.46 (0.77–2.76) | 13/17 | 1.35 (0.56–3.30) | ||||||
| rs7301328 | Codominant | G/G | 39/35 | 1 | 0.86 | 28/23 | 1 | 0.71 | 11/12 | 1 | 0.87 | |
| C/G | 72/73 | 1.13 (0.64–1.98) | 48/52 | 1.32 (0.67–2.60) | 24/21 | 0.80 (0.29–2.19) | ||||||
| C/C | 27/29 | 1.20 (0.60–2.40) | 18/19 | 1.29 (0.55–3.00) | 9/10 | 1.02 (0.30–3.44) | ||||||
| Dominant | G/G | 39/35 | 1 | 0.61 | 28/23 | 1 | 0.41 | 11/12 | 1 | 0.76 | ||
| C/G-C/C | 99/102 | 1.15 (0.67–1.96) | 66/71 | 1.31 (0.69–2.50) | 33/31 | 0.86 (0.33–2.24) | ||||||
| Recessive | G/G-C/G | 111/108 | 1 | 0.74 | 76/75 | 1 | 0.85 | 35/33 | 1 | 0.75 | ||
| C/C | 27/29 | 1.10 (0.61–1.99) | 18/19 | 1.07 (0.52–2.20) | 9/10 | 1.18 (0.43–3.26) | ||||||
| Overdominat | G/G-C/C | 66/64 | 1 | 0.85 | 46/42 | 1 | 0.56 | 20/22 | 1 | 0.59 | ||
| C/G | 72/73 | 1.05 (0.65–1.68) | 48/52 | 1.19 (0.67–2.11) | 24/21 | 0.80 (0.34–1.85) | ||||||
| rs1806191 | Codominant | G/G | 98/88 | 1 | 0.44 | 71/62 | 1 | 0.32 | 27/26 | 1 | 1 | |
| A/G | 37/44 | 1.32 (0.78–2.24) | 22/29 | 1.51 (0.79–2.89) | 15/15 | 1.04 (0.42–2.54) | ||||||
| A/A | 3/5 | 1.86 (0.43–7.99) | 2/4 | 2.29 (0.41–12.94) | 1/1 | 1.04(0.06–17.49) | ||||||
| Dominant | G/G | 98/88 | 1 | 0.23 | 71/62 | 1 | 0.15 | 27/26 | 1 | 0.93 | ||
| A/G-A/A | 40/49 | 1.36 (0.82–2.27) | 24/33 | 1.57 (0.84–2.95) | 16/16 | 1.04 (0.43–2.50) | ||||||
| Recessive | G/G-A/G | 135/132 | 1 | 0.46 | 93/91 | 1 | 0.4 | 42/41 | 1 | 0.99 | ||
| A/A | 3/5 | 1.70 (0.40–7.27) | 2/4 | 2.04 (0.37–11.44) | 1/1 | 1.02(0.06–16.93) | ||||||
| Overdominat | G/G-A/A | 101/93 | 1 | 0.33 | 73/66 | 1 | 0.25 | 28/27 | 1 | 0.94 | ||
| A/G | 37/44 | 1.29 (0.77–2.17) | 22/29 | 1.46 (0.76–2.78) | 15/15 | 1.04 (0.43–2.52) | ||||||
a* Indicates that p-value is statistically significant after FDR correction