Fig. 2.
Differential expression analysis for SARM1 validated dysregulation of risk genes at transcription level in multiple tissues. The boxplot shows the differential expression analysis results of SARM1 between ALS patients and healthy control individuals in lower motor neurons, skeletal muscle, and whole blood. The p value was obtained from the t test. a NALS = 6 and NControl = 6. SARM1 was downregulated in lower motor neurons (p = 7.64 × 10−3). b NALS = 9 and NControl = 18. SARM1 was downregulated in skeletal muscle (p = 9.34 × 10−3). c NALS = 233 and NControl = 508. SARM1 was downregulated in whole blood (p = 1.94 × 10−3). ALS, amyotrophic lateral sclerosis. #p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001