Table 1.
Proteome-wide significant genes for amyotrophic lateral sclerosis in two datasets
| ROSMAP dataset | Banner dataset | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | CHR | PWAS.z | PWAS.p | FDR.p | PWAS.z | PWAS.p | FDR.p | Replicated |
| SCFD1 | 14 | 7.32 | 2.56E-13 | 3.68E-10 | - | - | - | - |
| SARM1 | 17 | − 5.20 | 2.00E-07 | 1.44E-04 | − 5.20 | 2.00E-07 | 2.24E-04 | Yes |
| TMEM175 | 4 | − 4.75 | 1.99E-06 | 9.55E-04 | - | - | - | - |
| BCS1L | 2 | − 4.68 | 2.83E-06 | 1.02E-03 | − 3.89 | 1.02E-04 | 4.86E-02 | Yes |
| WIPI2 | 7 | − 4.19 | 2.84E-05 | 8.17E-03 | - | - | - | - |
| DHRS11 | 17 | − 3.97 | 7.28E-05 | 1.75E-02 | - | - | - | - |
This table shows the 6 significant genes identified in the ALS PWAS and the z scores with their corresponding p values and FDR-adjusted p values. CHR, chromosome; PWAS, proteome-wide association study; ROSMAP, Religious Orders Study and Rush Memory and Aging Project