TABLE 7.

Classification statistics for enzymatic activity of active substances extracted from the coral.

Active ingredient	Source	Related active substance	Concentration a	Effect	Reference
Sesquiterpenoids	Sinularia cf. molesta	PTP1B	1.24 μmol/L (IC50)	Inhibitor	Chu et al. (2018)
Diterpene	Sarcophyton trocheliophorum	PTP1B	6.97 μmol/L (IC50)	Inhibitor	Liang et al. (2013)
Diterpene	Sinularia crassa	α-Glucosidase	10.65±0.16, 30.31±1.22 μmol/L (IC50)	Inhibitor	Wu et al. (2020b)
Diterpene	Sinularia polydactyla	PTP1B	51.8–72.4 μmol/L (IC50)	Inhibitor	Ye et al. (2018)
Diterpene	Sarcophyton glaucum	Cytochrome P450 1A	1 µg/mL (Y)	Inhibitor	Hegazy et al. (2012)
Diterpene	Sarcophyton glaucum	Glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH)	10 µg/mL (Y)	Inducer	Hegazy et al. (2012)
Diterpene	Sarcophyton trocheliophorum	Acetylcholinesterase	40 μmol/L (Y)	Inhibitor	He (2013)
Diterpenoid alkaloids	Ellisella robusta ※ and Ellisella curvata ※	Tyrosine kinase c-Met	10 μmol/L (Y)	Inhibitor	Zhang (2012b)
Steroids	Sinularia dissecta	COX-2 (cyclooxygenase-2)	7.04 ± 1.03 μmol/L (IC50)	Inhibitor	Jin (2005)
Prostaglandin	Plexaura homomalla	P38α-kinase, Src-kinase, and topoisomerase IIα	2.5 and 10 μmol/L (Y)	Inhibitor	Hurtado et al. (2020)

^a Y refers to the medication.