Table 3.

Change in UPDRS Total and Motor score after 12 months of treatment with safinamide

	12-months FUP vs baseline (N = 363)
UPDRS: Change in total scores (subscales I, II, and III)	<  = −4.3 points	137 (37.7%)
	> −4.3 points*	210 (57.9%)
	NA	16 (4.4%)
UPDRS Part III: Change in motor examination score	<  = −2.5 points	156 (43.0%)
	> −2.5 points*	197 (54.3%)
	NA	10 (2.8%)

FUP Follow-up; NA Not available; *An increase in UPDRS Total score > 4.3 points and in UPDRS Part III > 2.5 points was considered as clinically significant according to Shulman et al. [14]. UPDRS, Unified Parkinson’s Disease Rating Scale