Table 2.
Incidence of PDD according to quartiles of glucose variability (CV).
| Glucose variability | Patients (N) |
Event (n) |
Person-years (PYs) |
Incidence rate (per 1,000 PYs) | Model 1* | Model 2** |
|---|---|---|---|---|---|---|
| quartile 1 | 2,314 | 372 | 20,352 | 18.28 | 1 (ref) | 1 (ref) |
| quartile 2 | 2,327 | 420 | 20,190 | 20.80 | 1.30 (1.03–1.63) | 1.30 (1.04–1.63) |
| quartile 3 | 2,301 | 441 | 19,292 | 22.91 | 1.30 (1.03–1.63) | 1.29 (1.02–1.62) |
| quartile 4 | 2,322 | 523 | 17,949 | 29.14 | 1.50 (1.20–1.87) | 1.50 (1.19–1.88) |
*Model 1 was adjusted for age, sex, presence of hypertension, diabetes and hyperlipidemia, heavy alcohol consumption, smoking, and regular exercise in the Fine and Gray competing regression model including glucose variability as a separate predictor, and death as a competing risk.
**Model 2 was adjusted for all covariates in model 1 plus systolic BP, diastolic BP, fasting glucose, total cholesterol, and BMI at index health examination in the Fine and Gray competing regression model.
PDD, Parkinson’s disease dementia; CV, coefficient of variation; PY, person-year; BP, blood pressure; BMI, body mass index.