TABLE 2.
Effects of ephaptic geometry and diffusion properties on ephaptic recovery times.
Ephaptic geometry | Diffusion parameters | Computational parameters | Computational results | ||||
---|---|---|---|---|---|---|---|
Ephaptic radius, a nm | Axial distance, w, nm | Na+ diffusion coefficient, D Na, nm2.s-1 | Cl− diffusion coefficient, D Cl, nm2.s-1 | Mesh size, nm | Stepsize interval, ms | Computation duration, ms | Time taken for 99.97% recovery ms |
4,000 | 20 | 1.3 109 | 2 109 | 400 | 0.01 | 20 | |
8,000a | 400 | 0.01 | 80 | ||||
12,000b | 800 | 0.01 | 180 | ||||
24,000 | 1,200 | 0.08 | 720 | ||||
40,000c | 1,600 | 0.40 | 2000 | ||||
8,000 | 5 | 1.3 109 | 2 109 | 400 | 0.01 | 80 | |
10 | 400 | 0.01 | 80 | ||||
20 | 400 | 0.01 | 80 | ||||
40 | 400 | 0.01 | 80 | ||||
12,000 | 5 | 1.3 109 | 2 109 | 800 | 0.02 | 180 | |
10 | 800 | 0.02 | 180 | ||||
20 | 800 | 0.01 | 180 | ||||
40 | 800 | 0.01 | 180 | ||||
8,000 | 20 | 0.65 109 | 1.0 109 | 400 | 0.01 | 160 | |
1.3 109 | 2 109 | 400 | 0.01 | 80 | |||
2.6 109 | 4 109 | 800 | 0.01 | 40 | |||
12,000 | 20 | 0.65 109 | 1.0 109 | 800 | 0.02 | 360 | |
1.3 109 | 2 109 | 800 | 0.01 | 180 | |||
2.6 109 | 4 109 | 800 | 0.01 | 90 |
a-c: diameters of atriala, ventricularb, and purkinje cellc, cardiomyocytes.