Table 2.
Hazard ratio (HR) and 95% confidence intervals (CIs) of arthritis with weight change patterns across adulthood in the NHANES 1999–2018.
| Non-adjusted HR (95%CI), P | Adjust I HR (95%CI), P | Adjust II HR (95%CI), P | |
|---|---|---|---|
| Arthritis | |||
| Absolute weight change | |||
| Weight change within 2.5 kg | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Weight loss≥2.5 kg | 1.13 (0.98, 1.30) 0.1009 | 1.05 (0.91, 1.21) 0.5306 | 1.03 (0.89, 1.20) 0.6933 |
| Weight gain≥2.5 kg and < 10 kg | 1.11 (1.02, 1.20) 0.0166 | 1.03 (0.95, 1.12) 0.4609 | 1.02 (0.94, 1.12) 0.6268 |
| Weight gain≥10 kg and < 20 kg | 1.60 (1.47, 1.74) <0.0001 | 1.34 (1.24, 1.46) <0.0001 | 1.33 (1.22, 1.46) <0.0001 |
| Weight gain≥20 kg | 2.04 (1.87, 2.23) <0.0001 | 1.59 (1.45, 1.74) <0.0001 | 1.56 (1.42, 1.71) <0.0001 |
| Weight change patterns | |||
| Stable non-obese | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Obese to non-obese | 0.99 (0.73, 1.33) 0.9347 | 1.06 (0.79, 1.43) 0.6842 | 1.02 (0.75, 1.39) 0.8872 |
| Non-obese to obese | 1.77 (1.67, 1.89) <0.0001 | 1.58 (1.48, 1.68) <0.0001 | 1.55 (1.45, 1.66) <0.0001 |
| Stable obese | 1.57 (1.41, 1.74) <0.0001 | 1.76 (1.59, 1.96) <0.0001 | 1.74 (1.56, 1.95) <0.0001 |
| Osteoarthritis | |||
| Absolute weight change | |||
| Weight change within 2.5 kg | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Weight loss≥2.5 kg | 1.17 (0.94, 1.47) 0.1654 | 1.07 (0.85, 1.34) 0.5539 | 0.96 (0.77, 1.21) 0.7501 |
| Weight gain≥2.5 kg and < 10 kg | 0.86 (0.75, 0.99) 0.0341 | 0.83 (0.72, 0.96) 0.0101 | 0.91 (0.79, 1.04) 0.1679 |
| Weight gain≥10 kg and < 20 kg | 1.39 (1.21, 1.60) <0.0001 | 1.21 (1.05, 1.39) 0.0080 | 1.32 (1.15, 1.53) <0.0001 |
| Weight gain≥20 kg | 1.96 (1.70, 2.26) <0.0001 | 1.54 (1.33, 1.78) <0.0001 | 1.50 (1.30, 1.74) <0.0001 |
| Weight change patterns | |||
| Stable non-obese | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Obese to non-obese | 1.60 (1.07, 2.40) 0.0232 | 1.47 (0.98, 2.21) 0.0616 | 1.20 (0.80, 1.79) 0.3882 |
| Non-obese to obese | 2.07 (1.86, 2.31) <0.0001 | 1.81 (1.63, 2.02) <0.0001 | 1.66 (1.49, 1.85) <0.0001 |
| Stable obese | 1.94 (1.64, 2.30) <0.0001 | 2.03 (1.72, 2.41) <0.0001 | 1.80 (1.52, 2.13) <0.0001 |
| Rheumatoid arthritis | |||
| Absolute weight change | |||
| Weight change within 2.5 kg | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Weight loss≥2.5 kg | 1.08 (0.79, 1.47) 0.6314 | 0.98 (0.72, 1.34) 0.9141 | 0.87 (0.63, 1.18) 0.3702 |
| Weight gain≥2.5 kg and < 10 kg | 0.83 (0.69, 1.00) 0.0469 | 0.81 (0.67, 0.98) 0.0306 | 0.90 (0.75, 1.09) 0.2944 |
| Weight gain≥10 kg and < 20 kg | 1.27 (1.05, 1.54) 0.0118 | 1.13 (0.94, 1.37) 0.1994 | 1.32 (1.09, 1.60) 0.0048 |
| Weight gain≥20 kg | 1.72 (1.41, 2.10) <0.0001 | 1.37 (1.12, 1.68) 0.0024 | 1.32 (1.08, 1.62) 0.0074 |
| Weight change patterns | |||
| Stable non-obese | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Obese to non-obese | 1.95 (1.19, 3.21) 0.0083 | 1.69 (1.03, 2.78) 0.0396 | 1.17 (0.71, 1.93) 0.5360 |
| Non-obese to obese | 1.96 (1.68, 2.27) <0.0001 | 1.71 (1.47, 1.99) <0.0001 | 1.46 (1.25, 1.70) <0.0001 |
| Stable obese | 1.83 (1.45, 2.32) <0.0001 | 1.84 (1.45, 2.34) <0.0001 | 1.58 (1.24, 2.00) 0.0002 |
Non-adjusted model adjust for: None.
Adjust I model adjust for: sex, race, education level, baseline age.
Adjust II model adjust for: sex, race, education level, baseline age, marital status, smoke status, family poverty income ratio, and history of malignancy.