TABLE 5.
Information on the identification of differential endogenous metabolites in the urine of rats with blood deficiency (trend: model vs. control group).
| No. | TR (time) | Adduct | VIP | Molecular formula | Metabolites | MS/MS fragment ion (m/z) | Trend |
|---|---|---|---|---|---|---|---|
| m/z (ESI+) | |||||||
| 1 | 13.16 | 751.5080 [M + Na]+ | 4.39 | C41H76O8P | Cardiolipins (CL) | 329.2477, 603.5331, 738.5012 | ↓ |
| 2 | 0.66 | 369.4645 [M + H]+ | 1.91 | C20H32O6 | Endoperoxide G2 | 295.1094 | ↑ |
| 3 | 7.34 | 315.2060 [M + H]+ | 1.89 | C19H26N2O2 | Unknown | 286.1544 | ↓ |
| 4 | 6.71 | 289.2260 [M + Li]+ | 1.79 | C19H26N2 | Aspidospermidine (Feng, 2019) | 41.0386, 255.1809, 267.1809 | ↓ |
| 5 | 8.32 | 338.1875 [M + K]+ | 1.78 | C20H29NO | Unknown | 83.0851 | ↑ |
| 6 | 8.30 | 132.1019 [M + H]+ | 1.72 | C6H13NO2 | L-lsoleucine | 86.0979, 91.0541 | ↓ |
| 7 | 5.32 | 180.1727 [M + H]+ | 1.61 | C9H9NO3 | hippuric acid (Yang, 2019) | 91.1137, 119.0007 | ↓ |
| 8 | 1.21 | 819.4525 [M + H]+ | 1.61 | C41H72NO11PS | PA (LTE4/i-15:0) | 189.0935, 391.2663 | ↑ |
| 9 | 1.07 | 216.1233 [M + Na + H]+ | 1.59 | C6H8O7 | Citric acid (Huang et al., 2020) | 133.0137 | ↓ |
| 10 | 4.93 | 863.6179 [M + H]+ | 1.57 | C46H87NO13 | Galabiosylceramide (Ferraris et al., 2022) | 145.0501,163.0598, 708.5770 | ↓ |
| 11 | 7.19 | 234.0516 [M+2Na] + | 1.54 | C7H12N2O4 | Glycylhydroxyproline | 44.9965 | ↓ |
| 12 | 13.14 | 795.9741 [M + Li]+ | 1.52 | C42H77O11P | PA (i-19:0/PGE1) | 96.9685 | ↑ |