Table 2.
Multivariate competing risk analysis of protein concentration at Day 14 in relation to rate of Relapse and GvHD outcomes.
| Relapse-related mortality | Non-relapsemortality | AGvHD | CGvHD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adj. HRSD | Adj.CI | p | Adj. HRSD | Adj.Cl | p | Adj. HRSD | Adj.Cl | p | Adj. HRSD | Adj.CI | p | |
| CCL23 | 1.94 | (0.78 4.87) | 0.16 | 1.11 | (0.62 1.97) | 0.73 | 1.66 | (1.12 2.46) | 0.01 | 1.14 | (0.79 1.64) | 0.5 |
| CDCP1 | 2.41 | (1.27 4.56) | 0.01 | 1.26 | (0.82 1.94) | 0.29 | 0.93 | (0.64 1.35) | 0.7 | 0.9 | (0.59 1.38) | 0.64 |
| CSF-1 | 0.93 | (0.34 2.54) | 0.88 | 1.57 | (0.95 2.6) | 0.08 | 0.95 | (0.6 1.51) | 0.83 | 0.7 | (0.39 1.24) | 0.22 |
| CXCL10 | 0,57 | (0.32 1.02) | 0.06 | 1.29 | (0.76 2.2) | 0.34 | 0.89 | (0.59 1.35) | 0.6 | 0.96 | (0.64 1.42) | 0.83 |
| IL6 | 0.47 | (0.22 1) | 0.05 | 1.5 | (1 2.23) | 0.05 | 1.13 | (0.77 1.65) | 0.54 | 1.14 | (0.75 1.71) | 0.54 |
| LIF-R | 1.48 | (0.66 3.3) | 0.35 | 0.47 | (0.28 0.77) | 0 | ||||||
| PD-L1 | 0.6 | (0.24 1.5) | 0.28 | 1.35 | (0.71 2.55) | 0.36 | 0.87 | (0.5 1.52) | 0.62 | 1.5 | (0.8 2.82) | 0.2 |
| TNFRSF9 | 2.39 | (0.81 7.03) | 0.11 | 0.75 | (0.4 1.41) | 0.37 | 0.99 | (0.69 1.42) | 0.95 | 0.85 | (0.53 1.36) | 0.5 |
Multivariate subdistribution hazard ratios (adj. HRSD) with a 95% confidence interval (CI) based on FG models of Relapse related mortality, Non-relapse mortality, acute GvHD and chronic GvHD. Models adjusted for variables retained after LASSO selection, excluding any variable in violation of proportional hazards assumption.