FIGURE 1.

Levels of cardiac troponin T (cTnT), a biomarker of cardiac damage, and examination of systolic function in rabbits after 5 and 10 weekly doses of DAU. (A) Plasma concentrations of cardiac troponin T as a marker of cardiac damage. (B) Echocardiography-assessed left ventricular systolic function (FS - fractional shortening). (C) Catheterization-assessed index of the left ventricular systolic function (dP/dtmax). The results are shown as median values, with boxes and whiskers representing the interquartile range and the 5th–95th percentile, respectively (A), or as the mean value ± SD (B,C). Significant differences are displayed as follows: p < 0.05 (*); p < 0.01 (**); p < 0.001 (***). 5 weeks corresponds to 5x DAU 3 mg/kg/week (cumulative dose ∼ 250 mg/m²); 10 weeks corresponds to 10x DAU 3 mg/kg/week (cumulative dose ∼ 500 mg/m²).