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. 2024 Jan 3;14:1298172. doi: 10.3389/fphar.2023.1298172

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Copyright © 2024 Adamcova, Parova, Lencova-Popelova, Kollarova-Brazdova, Baranova, Slavickova, Stverakova, Mikyskova, Mazurova and Sterba.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma levels of miR-34a-5p, the correlations with expression in LV, and quantitative indices of toxic damage to the heart in rabbits after 10 weekly doses of DAU. miR-34a-5p expression in plasma vs. miR-34a-5p expression in the left ventricular myocardium. miR-34a-5p expression in plasma vs. plasma concentrations of cardiac troponin T, a marker of cardiac damage. miR-34a-5p expression in plasma vs. echocardiography-assessed left ventricular systolic function (FS - fractional shortening). miR-34a-5p expression in plasma vs. catheterization-assessed index of the left ventricular systolic function (dP/dtmax). The statistical significance of changes is displayed as follows: p < 0.05 (*); p < 0.01 (**); p < 0.001 (***).