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. 2024 Jan 16;14:1436. doi: 10.1038/s41598-024-51779-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vitamin D-regulated pathways in CD4⁺ T cells determined through weighted gene co-expression network analysis. (A) Consensus modules of healthy control (HC) and multiple sclerosis (MS) groups. For each module, the number represents the correlation coefficient between their respective module eigengene (ME) and plasma 25(OH)D level, and the number in brackets represents the P-value. (B) Functional enrichment results for the “light yellow” module, with the top 30 enriched Hallmark gene sets and pathways shown. X-axis represents the number of genes of interest present in the annotated term, and bar color represents the false discovery rate (FDR).