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. 2024 Jan 16;14:1378. doi: 10.1038/s41598-023-50912-9

Table 1.

Components of the External Quality Assessment (EQA) specimen panel.

Specimen Copies of SARS-CoV-2 per mLa or Cq value for not-quantified pathogens Specimens used in EQA round Strain, source
SARS-CoV-2 (SARS2_H) 1.28 × 105 1, 2, 3 hCoV-19/Netherlands/NoordBrabant_10003/2020, RIVM
SARS-CoV-2 (SARS2_L)b 1.28 × 103 1, 2, 3
SARS-CoV-2 (SARS2_Edu) 1.28 × 102 1, 2, 3
SARS-CoV-2 Alpha_H 3.39 × 105 2 hCoV-19/Netherlands/NH-RIVM-20432/2020 B.1.1.7 20B/501Y.V1 , RIVM
SARS-CoV-2 Alpha_L 3.39 × 104 3
SARS-CoV-2 Beta 1.15 × 104 3 hCoV-19/Netherlands/NH-RIVM-10159/2021, RIVM
SARS-CoV-2 Gamma 8.77 × 103 3
SARS-CoV-1 Cq 28.57 (Sarbeco E-gene) 1, 2, 3 HKU-39849, kindly provided by Bart Haagmans, Erasmus MC
hCoV-NL63 Cq 28.10 (N-gene) 1, 2, 3 Clinical isolate, kindly provided by Lia van der Hoek, Amsterdam University Medical Center
hCoV-229E Cq 17.22 (N-gene) 1, 2 ATCC VR-740, ATCC, Manassas, Virginia
hCoV-OC43 Cq 27.77 (N-gene) 1, 2 ATCC VR-1558, ATCC, Manassas, Virginia
Influenza A (H3N2) Cq 22.76 (M-gene) 1 A/Netherlands/10,078/2020, RIVM
No virus control n/a 1,2,3 n/a

aCopies of E-gene determined by digital droplet PCR as described by Wolters et al., 2020 and Sluimer et al., 202117,18.

bSpecimen in duplicate in panel.