. Author manuscript; available in PMC: 2025 Jan 1.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2023 Jul 17;195(1):e32952. doi: 10.1002/ajmg.b.32952

TABLE 2.

Comparison of gastrointestinal polygenic scores between children with autism spectrum disorder and population controls, Study to Explore Early Development.

	Crude OR (95% CI)^a of ASD	Adjusted OR (95% CI)^b of ASD
Crohn’s disease PGS
All	0.87 (0.78–0.97)	0.97 (0.86–1.09)
European ancestry	0.91 (0.79–1.06)	0.91 (0.78–1.05)
Non-European ancestry	1.00 (0.82–1.21)	1.13 (0.90–1.41)
Ulcerative colitis PGS
All	0.86 (0.77–0.96)	1.07 (0.93–1.22)
European ancestry	1.08 (0.92–1.28)	1.08 (0.91–1.27)
Non-European ancestry	0.88 (0.74–1.06)	1.02 (0.82–1.28)
Inflammatory bowel disease PGS
All	0.86 (0.76–0.95)	1.06 (0.92–1.23)
European ancestry	1.05 (0.88–1.25)	1.03 (0.86–1.23)
Non-European ancestry	0.91 (0.76–1.08)	1.13 (0.86–1.48)

Abbreviations: ASD, autism spectrum disorder; CI, confidence interval; GI, gastrointestinal; OR, odds ratio; PGS, polygenic score.

Odds of ASD for each 1 SD unit increase in GI-PGS.

Odds of ASD for each 1 SD unit increase in GI-PGS, adjusted for 10 genetic ancestry principal components.