Table 4. Characteristics of the study patients with and without a conclusive diagnosis of Lynch syndrome.
| Characteristics | LS (n=10) | Non-LS (n=21) | p | |
|---|---|---|---|---|
| Age at first cancer diagnosis, years; median (range) | 57.4 (41–72.4) | 56.5 (38.7–88.9) | 0.447 | |
| Age at first cancer diagnosis (yr) | 0.379 | |||
| <50 | 1 (10) | 6 (28.6) | ||
| ≥50 | 9 (90) | 15 (71.4) | ||
| Age at diagnosis of EC, years; median (range) | 59.3 (45.4–72.5) | 56.5 (49.2–88.9) | 0.916 | |
| Age at diagnosis of EC (yr) | 1.000 | |||
| <50 | 1 (10) | 4 (19) | ||
| ≥50 | 9 (90) | 17 (81) | ||
| Age at diagnosis of CRC, years; median (range) | 58.5 (41–72.4) | 58.5 (38.7–90.1) | 0.612 | |
| Age at diagnosis of CRC (yr) | 1.000 | |||
| <50 | 1 (10) | 3 (14.3) | ||
| ≥50 | 9 (90) | 18 (85.7) | ||
| EC histology | 1.000 | |||
| Endometrioid | 9 (90) | 19 (90.5) | ||
| Non-endometrioid | 1 (10) | 2 (9.5) | ||
| CRC adenocarcinoma | 10 (100) | 21 (100) | ||
| EC FIGO stage | 1.000 | |||
| Stage I−II | 9 (90) | 19 (90.5) | ||
| Stage III−IV | 1 (10) | 2 (9.5) | ||
| CRC stage | 0.423 | |||
| Stage I−II | 5 (50) | 15 (71.4) | ||
| Stage III−IV | 5 (50) | 6 (28.6) | ||
| Temporal sequence of metachronous tumors | 1.000 | |||
| EC followed by CRC | 2 (20) | 3 (14.3) | ||
| CRC followed by EC | 5 (50) | 11 (52.4) | ||
| Synchronous EC/CRC | 3 (30) | 7 (33.3) | ||
Data are presented as counts, with percentages in parentheses, unless specified otherwise.
CRC, colorectal cancer; EC, endometrial cancer; FIGO, International Federation of Gynecology and Obstetrics; LS, Lynch syndrome.