Table 2. Adverse events.
| Adverse events | NCI-CTCAE 5.0 | ||||
|---|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | ||
| 60 mg/m2 (n=3) | |||||
| Neutropenia | 0 | 1 | 0 | 0 | |
| Anemia | 0 | 3 | 0 | 0 | |
| Thrombocytopenia | 1 | 0 | 0 | 0 | |
| 65 mg/m2 (n=3) | |||||
| Nausea and vomiting | 1 | 0 | 0 | 0 | |
| Bloating | 1 | 0 | 0 | 0 | |
| Anemia | 0 | 2 | 0 | 0 | |
| 70 mg/m2 (n=12) | |||||
| Nausea and vomiting | 2 | 1 | 0 | 0 | |
| Inappetence | 2 | 0 | 0 | 0 | |
| Dizziness | 3 | 0 | 0 | 0 | |
| Fatigue | 4 | 0 | 0 | 0 | |
| Bloating | 1 | 0 | 0 | 0 | |
| Diarrhea | 2 | 0 | 0 | 0 | |
| Neutropenia | 0 | 2 | 0 | 0 | |
| Anemia | 3 | 3 | 1 | 0 | |
| Thrombocytopenia | 0 | 1 | 0 | 0 | |
| 75 mg/m2 (n=12) | |||||
| Nausea and vomiting | 4 | 0 | 0 | 0 | |
| Bloating | 2 | 0 | 0 | 0 | |
| Diarrhea | 3 | 0 | 0 | 0 | |
| Neutropenia | 0 | 3 | 0 | 0 | |
| Anemia | 3 | 3 | 1 | 0 | |
| Thrombocytopenia | 1 | 0 | 0 | 1 | |
| Hepatic function impairment | 0 | 0 | 1 | 0 | |
| Hypokalemia | 0 | 2 | 0 | 0 | |
| Hyponatremia | 0 | 2 | 0 | 0 | |