A-D, CT scan imaging quantifying end-expiratory central airway collapse in four participants with COPD. A, B, Two participants with COPD without central airway collapse (defined as present if ≥ 50% decrement in cross-sectional airway lumen area from inspiration to expiratory scan). The participants showed a 4% (A) and 33% (B) reduction in cross-sectional lumen area within the trachea between end-inspiration and end-expiration CT scan imaging. C, D, Two participants with COPD with central airway collapse. The participant showed a 50% reduction (C) and a 66% reduction (D) in cross-sectional airway lumen area from inspiratory to expiratory scan, respectively.