Table 2.

Cox proportional hazards regression models for PFS and OS in the entire study population.

	PFS				OS
	Univariable models		Multivariable model		Univariable models		Multivariable model
Characteristics	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age (years)	—	0.412	—	—	—	0.813	—	—
<70	Ref	—	—	—	Ref	—	—	—
≥70	1.31 (0.69–2.48)	—	—	—	1.09 (0.52–2.28)	—	—	—
Sex	—	0.798	—	—	—	0.508	—	—
Female	Ref	—	—	—	Ref	—	—	—
Male	0.93 (0.56–1.56)	—	—	—	0.81 (0.44–1.50)	—	—	—
ECOG PS	—	0.001	—	0.026	—	<0.001	—	<0.001
0	Ref	—	Ref	—	Ref	—	Ref	—
≥1	2.39 (1.42–4.03)	—	1.88 (1.08–3.29)	—	3.32 (1.82–6.06)	—	3.04 (1.65–5.59)	—
Primary tumor location	—	0.247	—	—	—	0.630	—	—
Right	Ref	—	—	—	Ref	—	—	—
Left colon/Rectum	0.54 (0.19–1.52)	—	—	—	0.75 (0.23–2.43)	—	—	—
Primary tumor resection	—	0.498	—	—	—	0.453	—	—
No	Ref	—	—	—	Ref	—	—	—
Yes	0.80 (0.41–1.54)	—	—	—	1.31 (0.64–2.69)	—	—	—
Adjuvant CT	—	0.449	—	—	—	0.560	—	—
No	Ref	—	—	—	Ref	—	—	—
Yes	1.22 (0.73–2.06)	—	—	—	0.83 (0.44–1.56)	—	—	—
Metastatic sites (N)	—	0.487	—	—	—	0.218	—	—
1	Ref	—	—	—	Ref	—	—	—
>1	1.23 (0.68–2.22)	—	—	—	1.62 (0.75–3.51)	—	—	—
Prior treatment lines	—	0.288	—	—	—	0.065	—	—
1–2	Ref	—	—	—	Ref	—	—	—
≥3	1.32 (0.79–2.20)	—	—	—	1.79 (0.96–3.31)	—	—	—
PRESSING-HER2	—	<0.001	—	0.005	—	<0.001	—	0.007
Negative	Ref	—	Ref	—	Ref	—	Ref	—
Positive	3.49 (1.74–6.99)	—	3.06 (1.40–6.69)	—	3.79 (1.78–8.07)	—	2.93 (1.32–6.48)	—
HER CNV	—	<0.001	—	0.002	—	0.157	—	—
≥6	Ref	—	Ref	—	Ref	—	—	—
<6	4.63 (1.97–10.92)	—	3.89 (1.60–9.49)	—	1.87 (0.79–4.46)	—	—	—

Abbreviations: CT, chemotherapy; Ref, reference.