Table 1.
The design and characteristics of 8 studies included in a meta-analysis to compare the use of PCC and FFP in adult cardiac surgery
| Variable | PCC/FFP | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Arnékian et al. [11] (2012) | Bartoszko et al. [14] (2021) | Cappabianca et al. [12] (2016) | Fitzgerald et al. [15] (2018) | Karkouti et al. [3] (2021) | Ortmann et al. [20] (2015) | Green et al. [4] (2021) | Smith et al. [13] (2022) | |
| Type of study | Retrospective | Post-hoc | Retrospective | Retrospective | RCT | Retrospective | RCT | RCT |
| Follow-up (day) | NA | 28 | NA | NA | 28 | 30 | 90 | 30 |
| Patientsa) | 24/26 | 72/343 | 225/225 | 117/117 | 54/47 | 45/55 | 25/25 | 51/49 |
| Mean age (yr) | 64.0/72.0 | 59.4/65.3 | 69.2/69.7 | 59.6/58.9 | 62.8/65.2 | 61.0/62.0 | 68.3/65.6 | 70.0/67.6 |
| Femalea) | 6/8 | 30/99 | 91/91 | 40/45 | 14/14 | 19/18 | 9/9 | 25/14 |
| BMI (kg/m2) | 27±3.6/26±4 | 21±5/23±4.5 | 25±4.7/25±4.9 | NA | 23.6±4.5/23±4.7 | 28.8±6/27±5 | 27±6/29±5 | 28.6±6/29±5 |
| CPB time (min) | 310±50/317±8 | NA | 152±68/150±65 | 142±69/148±65 | 172±71/166±46 | 351±61/344±51 | NA | 164±76/160±63 |
| Diabetesa) | 6/6 | 12/72 | 37/36 | 15/20 | 11/10 | NA | 6/6 | NA |
| Hypertensiona) | 19/18 | NA | 142/143 | 65/67 | 36/31 | NA | 19/13 | NA |
| Emergent surgerya) | NA | 8/60 | 41/45 | 18/16 | 11/15 | NA | NA | NA |
| Elective surgerya) | NA | NA | NA | NA | NA | NA | 19/20 | NA |
| Procedureb) | ||||||||
| CABG | 9/9 | NA | 36/39 | NA | 20/15 | NA | NA | 1/0 |
| Valve surgery and CABG | 2/6 | NA | 53/47 | NA | NA | NA | 6/5 | 13/8 |
| Othersc) | 13/11 | NA | 136/140 | 88/92 | 106/87 | 45/55 | 5/7 | 37/41 |
| eGFR (mL/min/1.73 m2) | NA | NA | 64±26/64±23 | NA | NA | NA | NA | NA |
Values are presented as number or mean±standard deviation, unless otherwise stated.
PCC, prothrombin complex concentrate; FFP, fresh frozen plasma; RCT, randomized controlled trial; NA, not available; BMI, body mass index; CPB, cardiopulmonary bypass; CABG, coronary artery bypass graft; eGFR, estimated glomerular filtration rate.
a)Absolute number of patients. b)Absolute number of procedures. c)Examples of other procedures include: aortic replacement, mitral valve, tricuspid valve, single valve, surgery on aorta, multivalve repair, aortic replacement and valve repair, congenital defect repair, and pericardiectomy.