. Author manuscript; available in PMC: 2024 Jan 17.

Published in final edited form as: J Med Chem. 1996 Jul 19;39(15):2980–2989. doi: 10.1021/jm9600205

Table 5.

Affinity of and Selectivity Ratio for Selected Dihydropyridine Derivatives at Rat A₃ vs Human A₃, Rat A₁, and Rat A_2A Adenosine Receptors, Respectively

compd	K_i (μM)^a	selectivity ratio
compd	K_i (μM)^a	rA₃/hA₃	rA₁/rA₃	rA_2A/rA₃
12	11.0 ± 7.3	3.38	1.78	5.80
18	6.20 ± 2.12	2.24	0.13	5.66
24	12.1 ± 2.6	18.1	1.33	4.07
28	4.16 ± 1.55	38.6	1.43	1.15

Assayed in membranes from CHO cells stably expressing the cloned rat A₃ receptor using [¹²⁵I]-N⁶-(4-amino-3-iodobenzyl)-5′-(N-methylcarbamoyl)adenosine, as described previously.^13,28