. Author manuscript; available in PMC: 2024 Jan 17.

Published in final edited form as: J Med Chem. 1996 Jun 7;39(12):2293–2301. doi: 10.1021/jm950923i

Table 3.

Inhibition of Binding of [¹²⁵I]AB-MECA at Cloned Rat A₃ Receptors and Effects of Flavone Derivatives (50 μM) on the A₃ Agonist Elicited Inhibition of Adenylyl Cyclase

compd^b	K_i (μM) or % displacement	% inhibition of adenylyl cyclase^a
compd^b	K_i (μM) or % displacement	IB-MECA (10⁻⁷)	IB-MECA (10⁻⁶)
control		23.7 ± 5.1	35.3 ± 7.2
3a	18.2 ± 5.6	2.2 ± 2.2	19.1 ± 7.4
15	43 ± 3% (100 μM)	25.9 ± 2.4	39.2 ± 3.0
20	12.3 ± 6.6	21.2 ± 3.9	40.9 ± 3.7

Assayed in membranes from CHO cells stably expressing the rat A₃ receptor using a previously reported method^4,12 in the presence of 1 μM forskolin (n = 3).

For plot of results for compound 11e, refer to Figure 5.