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. 2023 Oct 17;6(4):709–728. doi: 10.20517/cdr.2023.62

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© The Author(s) 2023.

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Co-injection of SC263 tumor cells with Matrigel in Rag2 KO mice did not result in sustained tumor growth. (A and B) Tumor kinetics after s.c. injection with 5 × 10⁶ SC263-S: (A) and SC263-R cells; (B) (n = 3); (C and D) Tumor kinetics after s.c. injection with 2 × 10⁶ SC263-S: (C) and SC263-R cells; (D) mixed with 25% Matrigel (n = 4); (E and F) Tumor kinetics after s.c. injection with 2 × 10⁶ SC263-S: (E) and SC263-R cells; (F) mixed with 50% Matrigel (n = 4); (G and H) Tumor kinetics after s.c. injection with 1 × 10⁶ SC263-S: (G) and SC263-R cells; (H) mixed with 50% Matrigel (n = 4). Each line represents the data of one individual mouse. KO: Knock-out; -R: cetuximab-resistant HNSCC cell line; -S: cetuximab-sensitive HNSCC cell line; s.c.: subcutaneous.