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. 2023 Oct 17;6(4):709–728. doi: 10.20517/cdr.2023.62

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© The Author(s) 2023.

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Infiltration of macrophages is likely compromising the growth of SC263-S tumors and the resistance to cetuximab of SC263-R tumors in CB17 Scid mice. Representative images of immunohistochemical staining for Ki67 (proliferation), cleaved caspase-3 (apoptosis), F4/80 (macrophages), and NKp46 (NK cells), shown at 100x. Vehicle: PBS; Cet low: 2.5 mg/kg cetuximab; Cet medium: 10 mg/kg cetuximab. NK: Natural killer; PBS: phosphate-buffered saline; -R: cetuximab-resistant HNSCC cell line; -S: cetuximab-sensitive HNSCC cell line.