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. 2023 Oct 19;6(4):729–747. doi: 10.20517/cdr.2023.78

Table 3.

Natural compounds for anticancer drug resistance by inducing pyroptosis

Compounds Origin Structure Cancer Anti-drug resistant effects Refs
Betulinic acid Betula platyphylla Suk. graphic file with name cdr-6-4-729.in.T3.110.jpg Esophageal cancer Enhancing the antitumor effects of DDP by inducing pyroptosis via increasing the levels of ASC and caspase-1 and decreasing the levels of Ki67, PCNA, SOX2, and OCT4. [99]
Diosbulbin B Dioscorea bulbifera L. graphic file with name cdr-6-4-729.in.T3.210.jpg Gastric cancer Increasing DDP-sensitivity in gastric cancer by inducing pyroptosis via regulating the PD-L1/NLRP3 pathway. [106]
Ophiopogonin B Ophiopogon japonicus (L. f.) Ker-Gawl. graphic file with name cdr-6-4-729.in.T3.310.jpg Lung cancer Increasing DDP-sensitivity in gastric cancer by inducing pyroptosis via regulating the caspase-1/GSDMD pathway. [98]

ASC: Apoptosis-related speck-like protein; DDP: cisplatin; GSDMD: gasdermin D; NLRP3: NOD-like receptor family pyrin domain-containing 3; OCT4: octamer-binding transcription factor-4; PCNA: proliferating cell nuclear antigen; PD-L1: programmed death-ligand 1; SOX2: SRY-related high mobility group box protein-2.