TABLE 4.
Characteristics of first-degree relatives with definite hepatic steatosis
| First-degree relatives with hepatic steatosis (n = 47) | First-degree relatives without hepatic steatosis (N = 65) | p-value* | |
|---|---|---|---|
| Age (years)a | 43.5 (13.1) | 42.4 (15.3) | 0.69 |
|
| |||
| BMI (kg/m2)a | 35.2 (6.1) | 28.8 (5.2) | <0.0001 |
|
| |||
| Female, n (%) | 32 (68.1%) | 41 (63.1%) | 0.58 |
|
| |||
| Medical co-morbidities, n (%) | |||
| Hypertension | 19 (40.4%) | 16 (24.6%) | 0.07 |
| Hypercholesterolemia | 15 (31.9%) | 19 (29.2%) | 0.76 |
| Type 2 diabetes | 14 (29.8%) | 11 (17.2%) | 0.042 |
|
| |||
| Alcohol use (drinks/week) | |||
| None | 41 (87.2%) | 55 (84.6%) | 0.84 |
| 1–7 | 2 (4.3%) | 5 (7.7%) | |
| ≥ 7 | 4 (8.5%) | 5 (7.7%) | |
|
| |||
| Tobacco use, n (%) | 8 (17.0%) | 8 (12.3%) | 0.48 |
|
| |||
| Biochemical dataa | |||
| AST (IU/L) | 27.7 (19.9) | 22.6 (14.2) | 0.06 |
| ALT (IU/L) | 45.5 (30.7) | 32.9 (24.9) | 0.0007 |
| Bilirubin (mg/dl) | 0.5 (0.2) | 0.5 (0.3) | 0.96 |
| Albumin (g/dl) | 4.0 (0.3) | 4.0 (0.3) | 0.25 |
| Total cholesterol (mg/dl) | 186.1 (39.8) | 174.4 (36.7) | 0.17 |
| HDL (mg/dl) | 45.2 (9.6) | 51.8 (11.1) | 0.003 |
| LDL (mg/dl) | 105.2 (36.5) | 95.3 (31.7) | 0.25 |
| TG (mg/dl) | 178.6 (91.2) | 125.3 (80.8) | 0.0003 |
| Platelet count (109/L) | 253.1 (67.0) | 269.6 (58.5) | 0.094 |
| HbA1c (%) | 6.4 (1.5) | 6.1 (1.5) | 0.01 |
|
| |||
| FIB-4 indexa | 0.8 (0.4) | 0.7 (0.4) | 0.24 |
|
| |||
| FIB-4 Ȧ 2.67, n (%) | 0 | 1 (1.6%) | 1.00 |
Note: Bold values represent the significance of p-value (p < 0.05).
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HbA1c, glycated haemoglobin; HCC, hepatocellular carcinoma; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TG, triglycerides.
a
Mean (SD).
*
p-values for biochemical data from Wilcoxon two-sample test, otherwise from the t test, chi-square or Fisher’s as appropriate.