TABLE 1.

Overall quality metrics for model_1 submissions by selected methods.

Method	GDT_TS ≥ 45 (total targets)	GDT_TS ≥ 90 (total targets)	Median GDT_TS
PEZYFoldings	101 (107) = 94.4%	53 (107) = 49.5%	89.65
UM‐TBM	105 (109) = 96.3%	46 (109) = 42.2%	87.36
Yang	105 (108) = 97.2%	51 (108) = 47.2%	89.26
ColabFold	93 (109) = 85.3%	42 (109) = 38.5%	86.67
NBIS‐af2‐standard	93 (109) = 85.3%	38 (109) = 34.9%	85.88
ESM‐single‐sequence	72 (93) = 77.4%	19 (93) = 20.4%	77.71

Note: The best‐performing MSA‐based methods, the AF2 controls and the best pLM‐based method were chosen for the comparison. The GDT_TS threshold of 45 corresponds to a prediction of the correct topology ⁸ ; the 90 threshold is taken as the approximate difference between two crystal structures of the same protein. ⁷