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. Author manuscript; available in PMC: 2024 Jan 17.
Published in final edited form as: Aliment Pharmacol Ther. 2023 Jan 20;57(8):872–885. doi: 10.1111/apt.17362

TABLE 2.

Predictive diagnostic performance of established non-invasive models for different stages of liver fibrosis in the training and testing sets

Group Panel Content Training AUC Testing AUC
Stage F1 vs. F0
 All (n = 550) BA + Clinical panel WC + DBP + 6-ketoLCA + HDCA + dehydroLCA + TLCA + isoLCA + ALT + βCA 0.77 0.64
Non-invasive diagnostic index HFS 0.58 0.55
 Men (n = 396) BA + Clinical panel DBP + WC + 6-ketoLCA + TLCA + βCA + AST + HOMA-IR + CDCA-3Glu 0.80 0.69
Non-invasive diagnostic index HFS 0.67 0.54
 Women (n = 154) BA panel NorCA + UCA + THCA + TUDCA + TLCA + TCDCA + GHCA 0.88 0.80
Non-invasive diagnostic index HFS 0.75 0.65
 Obese (n = 431) BA + Clinical panel DBP + ALT + TLCA + βUCA + βCA + TCA + GCA 0.75 0.61
Non-invasive diagnostic index HFS 0.65 0.51
 Non-obese (n = 119) BA + Clinical panel dehydroLCA + DBP + HOMA-IR + 6-ketoLCA 0.78 0.69
Non-invasive diagnostic index HFS 0.71 0.66
 MetS (n = 377) BA + Clinical panel ALT + TLCA + NorCA/NorDCA +7-DHCA 0.70 0.59
Non-invasive diagnostic index HFS 0.65 0.59
 No-MetS (n = 173) BA panel HDCA/HCA 0.64 0.53
Non-invasive diagnostic index FIB-4 0.61 0.59
Stage F2–4 vs. F0–1
 All (n = 550) BA + Clinical panel 7-DHCA + WBC + TUDCA + BMI 0.64 0.58
Non-invasive diagnostic index HFS 0.55 0.60
 Men (n = 396) BA + Clinical panel UDCA/CDCA + WBC + βUDCA + βUCA + BMI 0.67 0.54
Non-invasive diagnostic index NFS 0.53 0.37
 Women (n = 154) BA panel 7-DHCA + HbA1c 0.75 0.65
Non-invasive diagnostic index HFS 0.62 0.56
 Obese (n = 431) BA + Clinical panel WBC + UCA + NorCA + GCA + TCA + GUDCA 0.65 0.51
Non-invasive diagnostic index HFS 0.56 0.60
 Non-obese (n = 119) BA + Clinical panel 7-DHCA/CA 0.71 0.66
Non-invasive diagnostic index FIB-4 0.60 0.43
 MetS (n = 377) BA + Clinical panel WBC + 7-DHCA 0.65 0.59
Non-invasive diagnostic index HFS 0.56 0.58
 No-MetS (n = 173) BA panel 7-DHCA + CDCA-3Glu/CDCA 0.61 0.59
Non-invasive diagnostic index NFS 0.57 0.46

Note: Panel type of predictive models, contents and performances in both the training cohorts and testing cohorts of different prediction models are reported. For the sake of clarity, the recommended prediction models with good performances have been marked in bold.