. 2023 Dec 29;63(2):1083–1101. doi: 10.1021/acs.inorgchem.3c03414

Table 7. Cytotoxicity Data of 7 and 10 toward Drug-Sensitive CCRF-CEM, Multidrug-Resistant CEM/ADR5000, and Healthy PBMC Cells Determined by Resazurin Reduction Assay^a.

compound	CCRF-CEM		CEM/ADR5000		PBMC		degree of resistance
	IC₅₀ (μM)	SD	IC₅₀ (μM)	SD	IC₅₀ (μM)	SD
7	0.78	0.02	7.17	0.53	1.72	0.09	9.19
10	0.52	0.08	5.56	1	10.15	0.73	10.69
cisplatin	5.82	0.16	3.28	0.41			0.56

All values are expressed as mean ± standard deviation (SD) of three independent experiments. The degree of resistance was calculated by dividing the IC₅₀ value of resistant cells by that of sensitive cells.

Table 7. Cytotoxicity Data of 7 and 10 toward Drug-Sensitive CCRF-CEM, Multidrug-Resistant CEM/ADR5000, and Healthy PBMC Cells Determined by Resazurin Reduction Assaya.

Table 7. Cytotoxicity Data of 7 and 10 toward Drug-Sensitive CCRF-CEM, Multidrug-Resistant CEM/ADR5000, and Healthy PBMC Cells Determined by Resazurin Reduction Assay^a.