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. 2023 Dec 18;7(1):44–58. doi: 10.1021/acsabm.3c00941

Table 1. Exosome-Associated Molecular Cargos Interlink in EMT.

exosome cargos molecules involvement in EMT references
Proteins PDL1 Induce the immune cell’s apoptosis and suppress the immune system (27)
FasL Induce cytotoxic T cells apoptosis and suppress the immune system (31)
Tetraspanins (CD9, CD63, CD81, CD151) Cancer angiogenesis, metastasis, EMT (100)
CD97 Premetastatic niche in gastric carcinoma cells (58)
Annexins, integrin α3, fibronectin, and metalloproteinase Extracellular matrix remodeling (34, 35)
Integrin Organ-specific metastasis (67)
Heat shock proteins It reduces NK cell-based anticancer response in cancer (101)
Lipids Membrane lipid Cell signaling (104, 105)
RNA miRNA-9 and miRNA-181a Breast cancer progression (25)
miRNA-425-5p, miRNA-130b-3p, and miRNA-25-3p M2 polarization (25)
DNA Genomic DNA, mitochondrial DNA, oncogenic DNA Reflect on the parental cell mutation status and it also related epigenetic regulation (102, 9)
Carbohydrate Glycans Cancer metastasis (103)