Fluorescence binding parameters for HSA–chalcone derivatives (pH-7.4).
Compounds | T (K) | k q (×1018 L mol−1 s−1) | k b (×106 L mol−1) | n | ΔH° (kJ mol−1) | ΔG° (kJ mol−1) | ΔS° (J mol−1 K−1) |
---|---|---|---|---|---|---|---|
Compound A | 293 | 6.91 | 3.26 | 1.02 | −188.05 | −55.11 | 18.02 |
298 | 3.96 | 2.90 | 1.05 | −56.05 | |||
303 | 3.57 | 2.66 | 1.08 | −56.99 | |||
Compound B | 293 | 5.20 | 4.43 | 0.93 | −141.70 | −44.16 | 15.38 |
298 | 4.76 | 4.23 | 0.95 | −41.81 | |||
303 | 4.26 | 4.17 | 1.01 | −42.45 | |||
Compound C | 293 | 5.71 | 1.57 | 0.98 | −184.10 | −45.05 | 14.75 |
298 | 5.53 | 1.40 | 1.41 | −45.79 | |||
303 | 4.95 | 1.33 | 1.03 | −46.53 |