Table 2.
Association between Elaeis guineensis (oil palm) pollen sensitization and the susceptibility of allergic diseases among house dust mite-sensitized individuals in the Singapore/Malaysia Chinese population.
| HDM-sensitized individuals (n = 8089) |
||||
|---|---|---|---|---|
|
Elaeis guineensis Positive SPT |
Elaeis guineensis Negative SPT |
P-value | OR (95% CI) | |
| Case/Control (%Case) | Case/Control (%Case) | |||
| Asthmaa | 146/350 (29.4) | 1443/4312 (25.1) | 0.0528 | 1.22 (1.00–1.50) |
| Allergic Rhinitis (AR)b | 296/155 (65.6) | 3075/2145 (58.9) | 0.00142∗ | 1.4 (1.14–1.72) |
| Atopic Dermatitis (AD)c | 134/329 (28.9) | 1235/4409 (21.9) | 1.18 x 10−4∗ | 1.52 (1.22–1.87) |
| Single allergic disease only (Asthma-only or AR-only or AD-only) | 206/90 (69.6) | 2651/1303 (67) | 0.212 | 1.18 (0.91–1.54) |
| At least one allergic disease (Asthma or AR or AD) | 376/90 (80.7) | 4076/1303 (75.8) | 0.00728∗ | 1.40 (1.10–1.79) |
| More than one allergic disease (disease multimorbidity) | 170/90 (65.4) | 1425/1303 (52.2) | 2.07 x 10−5∗ | 1.81 (1.38–2.38) |
| Asthma + AR | 94/121 (43.7) | 796/1647 (32.6) | 5.91 x 10−4∗ | 1.67 (1.24–2.23) |
| Asthma + AD | 43/224 (16.1) | 361/3064 (10.5) | 0.00365∗ | 1.68 (1.17–2.36) |
| AR + AD | 93/113 (45.1) | 772/1677 (31.5) | 2.84 x 10−5∗ | 1.87 (1.39–2.51) |
| Asthma + AR + AD | 30/90 (25) | 252/1303 (16.2) | 0.00944∗ | 1.81 (1.14–2.80) |
CI: confidence interval; HDM: house dust mite; OR: odds ratio; SPT: skin prick test. All data were evaluated based on skin prick test results of the Elaeis guineensis (oil palm) pollen allergen in a cross-sectional cohort of Singapore/Malaysia Chinese individuals with positive sensitization to house dust mite allergens (n = 8089). P-value, odds ratio, and 95% CI were calculated using a logistic regression analysis with adjustment for age and gender.
∗Logistic p < 0.05 is considered as significant.
Allergic asthma case was defined as ever having asthma positively diagnosed by a physician (Based on ISAAC questionnaire). Non-asthma control was defined as no symptoms and history of asthma.
Allergic rhinitis (AR) case is defined by 2 or more self-reported rhinitis symptoms. Non-AR control was defined as no symptoms and history of AR.
Atopic Dermatitis (AD) case is defined as having a persistent itchy rash that affected flexural areas. Non-AD control was classified based on no symptoms and history of AD