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. 2023 Dec 29;7(1):80–98. doi: 10.1021/acsabm.3c01058

Table 2. Classification of Stem Cells with Their Most Important Characteristics.

stem cell type characteristics ref
MSCs • self-renewal ability (36, 4043)
  • multipotent  
  • ease of access  
  • efficient in vitro expansion  
  • free of ethical concerns  
  • nonsignificant immune responses  
  • variable therapeutic results depending on the source and the donor  
ESCs • pluripotent (42, 4448)
  • ethical concerns  
  • possible tumor formation during the differentiation  
  • possible immune rejection after transplantation  
  • possible cell heterogeneity  
iPSCs • pluripotent (41, 42, 4750)
  • free of ethical concerns  
  • possible tumor formation during the differentiation  
  • possible immune rejection after transplantation  
  • possible cell heterogeneity  
NSCs • multipotent (42, 47, 5052)
  • efficient in vitro expansion  
  • secretion of neurotrophic factors  
  • less potential of forming tumors compared with ESCs  
Schwann cells • production of growth factors, cell adhesion molecules, and extracellular matrix proteins (41, 47)
  • myelinating function  
  • support of axonal regeneration  
  • efficacy and safety