Table 3.

Two-way ANOVA results for Figure 1.

Panel	Source of variation	F (DFn, DFd)	P value
B) Body weight vehicle-treated mothers	Diet	F (2, 13) = 9.55	P = 0.003
	Time	F (4.91, 63.87) = 12.50	P < 0.001
	Diet x Time	F (42, 273) = 4.40	P < 0.001
C) Body weight insulin-treated mothers	Diet	F (2, 10) = 5.83	P = 0.021
	Time	F (3.43, 34.3) = 7.24	P < 0.001
	Diet x Time	F (42, 210) = 2.61	P < 0.001
D) Body weight metformin-treated mothers	Diet	F (2, 13) = 27.31	P < 0.001
	Time	F (3.56, 46.21) = 3.70	P = 0.014
	Diet x Time	F (42, 273) = 2.86	P < 0.001
E) Maternal weight change	Diet	F (2, 47) = 14.00	P < 0.001
	Treatment	F (2, 47) = 2.31	P = 0.111
	Diet x Treatment	F (4, 47) = 0.66	P = 0.625
F) Food intake vehicle-treated mothers	Diet	F (2, 12) = 0.75	P = 0.494
	Time	F (2.93, 35.10) = 11.54	P < 0.001
	Diet x Time	F (40, 240) = 2.68	P < 0.001
G) Food intake insulin-treated mothers	Diet	F (2, 9) = 6.88	P = 0.015
	Time	F (5.77, 51.90) = 17.99	P < 0.001
	Diet x Time	F (40, 180) = 2.97	P < 0.001
H) Food intake metformin-treated mothers	Diet	F (2, 13) = 17.44	P < 0.001
	Time	F (6.19, 80.49) = 7.61	P < 0.001
	Diet x Time	F (40, 260) = 2.70	P < 0.001
I) Maternal cumulative food intake	Diet	F (2, 36) = 22.70	P < 0.001
	Treatment	F (2, 36) = 0.85	P = 0.435
	Diet x Treatment	F (4, 36) = 6.37	P < 0.001
J) Maternal glycemia	Diet	F (2, 83) = 10.20	P < 0.001
	Treatment	F (2, 83) = 1.53	P = 0.223
	Diet x Treatment	F (4, 83) = 0.35	P = 0.841
K) Maternal insulin levels	Diet	F (2, 34) = 0.99	P = 0.382
	Metformin	F (1, 34) = 7.21	P = 0.011
	Diet x Metformin	F (2, 34) = 0.84	P = 0.441
L) Maternal leptin levels	Diet	F (2, 39) = 18.99	P < 0.001
	Metformin	F (1, 39) = 9.75	P = 0.003
	Diet x Metformin	F (2, 39) = 0.05	P = 0.950
M) Maternal GDF15 levels	Diet	F (2, 27) = 0.90	P = 0.417
	Metformin	F (1, 27) = 10.27	P = 0.003
	Diet x Metformin	F (2, 27) = 0.86	P = 0.433