Table 1.

Differences in Demographic and Clinical Characteristics Between Patients in Sample 1 (RNA Seq) with Low and High Attentional Function Index Scores

Characteristic	High AFI (score of >7.5) 50.8% (n=94)	Low AFI (score of <5) 49.2% (n=91)	Statistics
	Mean (SD)	Mean (SD)
Age (years)	58.4 (10.0)	54.6 (13.2)	t = 2.23, p = 0.027
Education (years)	16.1 (3.1)	15.7 (3.0)	t = 1.01, p = 0.315
Body mass index (kg/m2)	26.6 (5.1)	27.0 (7.1)	t = −0.43, p = 0.665
KPS score	83.6 (11.6)	72.0 (11.7)	t = 6.78, p < 0.001
Number of comorbidities	2.1 (1.2)	3.1 (1.6)	t = −4.88, p < 0.001
SCQ score	4.5 (2.5)	7.5 (4.0)	t = −6.13, p < 0.001
AUDIT score	2.7 (2.3)	3.1 (3.1)	t = −0.90, p = 0.369
Time since diagnosis (years)	1.6 (2.9)	1.9 (3.2)	U, p = 0.308
Time since diagnosis (median)	0.44	0.45
Number of prior cancer treatments	1.5 (1.3)	1.6 (1.5)	t = −0.32, p = 0.751
Number of metastatic sites including lymph node involvement	1.3 (1.2)	1.2 (1.2)	t = 0.65, p = 0.515
Number of metastatic sites excluding lymph node involvement	0.8 (1.0)	0.7 (1.0)	t = 0.21, p = 0.837
MAX2 score	0.17 (0.08)	0.19 (0.08)	t = −1.85, p = 0.066
	% (n)	% (n)
Gender			FE, p = 0.010
Female	68.1 (64)	84.6 (77)
Male	31.9 (30)	15.4 (14)
Ethnicity			X2 = 7.90, p = 0.048 No significant post hoc contrasts
White	64.9 (61)	57.1 (52)
Black	13.8 (13)	22.0 (20)
Asian or Pacific Islander	9.6 (9)	2.2 (2)
Hispanic mixed or other	11.7 (11)	18.7 (17)
Married or partnered (% yes)	63.7 (58)	57.3 (51)	FE, p = 0.446
Lives alone (% yes)	19.6 (18)	24.4 (22)	FE, p = 0.476
Childcare responsibilities (% yes)	17.8 (16)	24.7 (22)	FE, p = 0.278
Care of adult responsibilities (% yes)	8.2 (7)	11.0 (9)	FE, p = 0.606
Currently employed (% yes)	47.9 (45)	24.2 (22)	FE, p = 0.001
Income			U, p = 0.044
<$30,000	18.4 (16)	28.9 (24)
$30,000 to <$70,000	19.5 (17)	26.5 (22)
$70,000 to <$100,000	24.1 (21)	15.7 (13)
≥$100,000	37.9 (33)	28.9 (24)
Specific comorbidities (% yes)
Heart disease	3.2 (3)	7.7 (7)	FE, p = 0.208
High blood pressure	29.8 (28)	35.2 (32)	FE, p = 0.530
Lung disease	4.3 (4)	14.3 (13)	FE, p = 0.022
Diabetes	11.7 (11)	16.5 (15)	FE, p = 0.401
Ulcer or stomach disease	6.4 (6)	7.7 (7)	FE, p = 0.780
Kidney disease	0 (0)	0 (0)	n/a
Liver disease	5.3 (5)	8.8 (8)	FE, p = 0.401
Anemia or blood disease	6.4 (6)	15.4 (14)	FE, p = 0.059
Depression	6.4 (6)	40.7 (37)	FE, p < 0.001
Osteoarthritis	10.6 (10)	14.3 (13)	FE, p = 0.508
Back pain	21.3 (20)	44.0 (40)	FE, p = 0.002
Rheumatoid arthritis	2.1 (2)	6.6 (6)	FE, p = 0.165
Exercise on a regular basis (% yes)	70.7 (65)	62.1 (54)	FE, p = 0.268
Smoking current or history (% yes)	26.1 (24)	40.4 (36)	FE, p = 0.058
Cancer diagnosis			X2 = 14.04, p = 0.003
Breast	34.0 (32)	40.7 (37)	NS
Gastrointestinal	45.7 (43)	22.0 (20)	0 > 1
Gynecological	14.9 (14)	22.0 (20)	NS
Lung	5.3 (5)	15.4 (14)	NS
Type of prior cancer treatment			X2 = 1.75, p = 0.627
No prior treatment	25.3 (23)	25.8 (23)
Only surgery, CTX, or RT	40.7 (37)	44.9 (40)
Surgery & CTX, or surgery & RT, or CTX & RT	22.0 (20)	14.6 (13)
Surgery & CTX & RT	12.1 (11)	14.6 (13)
CTX cycle length			X2 = 3.67, p = 0.159
14 day cycle	51.1 (48)	37.4 (34)
21 day cycle	42.6 (40)	56.0 (51)
28 day cycle	6.4 (6)	6.6 (6)
Emetogenicity of CTX			X2 = 2.48, p = 0.289
Minimal/low	17.0 (16)	18.7 (17)
Moderate	69.1 (65)	59.3 (54)
High	13.8 (13)	22.0 (20)
Antiemetic regimens			X2 = 1.95, p = 0.582
None	4.3 (4)	4.4 (4)
Steroid alone or serotonin receptor antagonist alone	17.4 (16)	16.5 (15)
Serotonin receptor antagonist and steroid	54.3 (50)	46.2 (42)
NK-1 receptor antagonist and two other antiemetics	23.9 (22)	33.0 (30)
Mean AFI score at enrollment	8.3 (0.7)	3.8 (0.9)	t = 37.89, p < 0.001

Abbreviations: AFI = Attentional Function Index; AUDIT = Alcohol Use Disorders Identification Test; CTX = chemotherapy; FE = Fisher’s exact test; kg = kilograms; KPS = Karnofsky Performance Status; m² = meter squared, n/a = not applicable; NK-1 = neurokinin-1; NS = not significant; RT = radiation therapy; SCQ = Self-administered Comorbidity Questionnaire; U = Mann-Whitney U test