FIG. 6.

Oral immunization with SREHP-H induces IgA anti-CTB antibodies in the stools and IgG anti-CTB antibodies in the sera of vaccinated mice. (A) IgA anti-CTB antibodies in stool samples from mice vaccinated with SREHP-H, MBP-H, CTB-SREHP-12, or CTB immediately before vaccination (day 0) and 14, 28, and 35 days after the initial vaccine dose. (B) IgG anti-CTB antibodies in sera from the same mice at the identical time points. Bars show the mean values ± the standard errors of the means (error bars) for groups of 7 to 10 mice. An asterisk over the bar indicates that the mean value was significantly higher (P < 0.05) than the preimmunization (day 0) mean. O.D. 405, optical density at 405 nm.