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. 2024 Jan 16;22:66. doi: 10.1186/s12967-023-04794-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — STC2 correlates with poor prognosis and promotes osteosarcoma proliferation and metastasis in vitro. A Kaplan–Meier survival analysis of STC2 in TARGET-OS cohort. B IHC staining of STC2 in 62 paraffin-embedded osteosarcoma tissues. Scale bar: 50 μm (left) and 100 μm (right). C, D Kaplan–Meier survival analysis of osteosarcoma patients stratified by STC2 expression level (n = 62). E Protein levels of STC2 in HFOB1.19 cells and several osteosarcoma cell lines by Western blot analysis. F Knockdown of STC2 in 143B and SJSA-1 osteosarcoma cells. G Cell proliferation, H colony formation, I, J Migration and invasion ability of STC2 knockdown 143B and SJSA-1 cells. *p < 0.05, **p < 0.01, ***p < 0.001