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. 2024 Jan 17;24:33. doi: 10.1186/s12935-024-03224-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Overexpression and an oncogenic role of USP29 in gastric cancers. (A) Left: Representative immunohistological images of USP29 in 5 normal gastric tissues and 35 tumors. Scale bar: 20 μm; right: Quantifications of the immunohistochemistry in the left are shown. (B) USP29 protein expression in 9 gastric tumors and paired non-cancerous tissues analyzed using Western blot. (C) Cell proliferation of MGC-803 and SNU-216 cells with or without USP29 overexpression. (D) Cell proliferation of MGC-803 and SNU-216 cells with or without USP29 depletion by specific sgRNAs. (E) Cell proliferation of MGC-803 and SNU-216 cells with or without USP29 knockdown by specific shRNAs. Data shown were obtained from mean ± SD of technical triplicates (C-E). (F) MGC-803 xenograft tumor growth curves and tumor image (n = 6). (G) Tumor weights of MGC-803 xenografts (n = 6). Data shown were obtained from mean ± SD of technical triplicates (F, G). (H) Representative immunohistological images of Ki-67 and cleaved-caspase-3 in MGC-803 xenograft tumors. Scale bar: 100 μm. (I) Quantifications of the immunohistochemistry in H. **p < 0.01